2型糖尿病患者氧化应激与抗氧化状态药物干预效果  

Effect of the drug on the oxidation stress and antioxidation condition in type 2 diabetes mellitus

作　　者：薛现中[1] 郭宏[1] 庞德水[1] 任忠法[1] 薛现霞[1] 王开芹[1] 陈玉萍[1] 

机构地区：[1]山东省滕州市中心人民医院内分泌科,滕州277500

出　　处：《中国实用医刊》2008年第20期4-6,共3页Chinese Journal of Practical Medicine

摘　　要：目的观察吡格列酮对2型糖尿病患者氧化应激和抗氧化指标的影响并探讨其可能机制。方法选择符合WHO1999年诊断标准的2型糖尿病患者70例，随机分为治疗组（35例）和对照组（35例）。治疗组降糖药物选用胰岛素＋吡格列酮，对照组仅用胰岛素控制血糖，其他常规治疗药物中不用血管紧张素转换酶抑制剂（ACEI）、他汀类、维生素C、维生素E等药物。疗程3个月。所有病人治疗前后均于清晨空腹抽血，留取标本，分别用于血清硝化酪氨酸（NT）、12（S）-羟基二十碳四烯酸[12（S）-HETE]、谷胱甘肽（GSH）、谷胱甘肽过氧化物酶（GSH—PX）等的测定。结果70例病人共有65例完成了本观察，两组病人治疗后氧化应激指标NT和12（S）-HETE水平均较治疗前有明显降低（P均〈0．01），治疗后两组相比治疗组NT和12（S）-HETE下降水平明显高于对照组（P分别〈0．01和〈0．05）。两组病人治疗后抗氧化指标GSH和GSH—PX水平均较治疗前有提高（P分别〈0．05和〈0．01），治疗后两组相比治疗组GSH和GSH—PX升高水平高于对照组（P分别〈0．01和〈0．05）。在治疗中无一例病人出现明显不良反应。结论吡格列酮具有独立于降血糖作用外的抗氧化作用，可以降低糖尿病患者血中氧化应激指标NT和12（S）-HETE水平，并升高GSH和GSH—PX抗氧化指标水平，改善2型糖尿病患者氧化应激状态提高其抗氧化能力。Objective To investigate the effect and mechanism of pioglitazone on oxidation stress and antioxidation conditions in patients of type 2 diabetes mellitus（T2DM）. Methods Seventy patients of T2DM, diagnosed according to the standards of WHO, 1999, were divided randomly into treated group （ n = 35 ） and control group （ n = 35 ）. Patients of the former group were treated with insulin and pioglitazone, while the latter were given insulin only to control blood glucose level. In other normal therapies,ACEI, statins, Vitamin C and Vitamin E were excluded. All patients were treated for 3 months. Fasting blood samples were got before and after treatment and reserved for measurement of NT, 12 （ S ） - HETE, GSH and GSH - PX. Results Sixty - five patients underwent the whole observation. The level of NT and 12（S） - HETE decreased markedly after treatment in both groups （ P 〈0.01 ）,with more significant in treated group than in control group （ P 〈 0. 01 and P 〈 0.05）. The levels of GSH and GSH - PX elevated markedly after treatment in both groups （ P 〈 0.01 and P 〈 0.05, respectively）, with more significant in treated group than in control group （ P 〈0. 01 and P 〈 0.05 ）. No adverse reactions were found during the treating process. Conclusion Pioglitazone shows antioxidant potency safely independent of glucose - lowering effect by decreasing of level of oxidation stress NT and 12（S） -HETE and increasing of level of antioxidant GSH and GSH -PX.

关 键 词：2型糖尿病 氧化应激 吡格列酮 血清硝化酪氨酸 12(S)-羟基二十碳四烯酸 谷胱甘肽 谷胱甘肽过氧化酶 

分 类 号：R587[医药卫生—内分泌]