融斑通脉颗粒对大鼠缺血再灌注所致心肌梗死的影响  

Effect of Rongban Tongmai Granules on ischemia-reperfusion induced myocardial infarction in rats

作　　者：张兰芳[1] 赵喜林[1] 邓锐 马晓斌[3] 王杨慧[3] 

机构地区：[1]无锡卫生高等职业技术学校,江苏无锡214111 [2]无锡山禾药业股份有限公司,江苏无锡214062 [3]中国中医研究院西苑医院,北京100091

出　　处：《中国生化药物杂志》2008年第5期327-329,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的观察融斑通脉颗粒对大鼠缺血再灌注所致心肌梗死的影响。方法以大鼠缺血再灌注所致的心肌梗死模型,通过测定血清超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量、以硝基四氮唑蓝(N-BT)染色法测定梗死面积、梗死区重量,观察融斑通脉颗粒对心肌梗死程度的影响。结果融斑通脉颗粒组大鼠的梗死面积和梗死区重量明显低于模型组,而血清SOD活性增加、MDA含量降低。结论融斑通脉颗粒能减轻大鼠缺血再灌注所致的心肌梗死程度。Purpose To observe the effect of Rongban Tongmai Granules on ischemia-reperfusion induced myocardial infarction in rats. Methods After establishing myocardial infarction rat models induced by ischemia-repeffusion, the infarct size, weight as well as the serum super oxide dismutase （SOD） and malonaldehyde （MDA） were measured to find out the effect of Rongban Tongmai Granules on ischemia-reperfusion induced Myocardial infarction in rats. Results Myocardial infarct size and weight were significantly smaller for rats given the treatment with Rongban Tongmai Granules than the model rats. in rats treatment with Rongban Tongmai Granules the activity of SOD was higher while the MDA was lower. Conclusion Rongban Tongmai Granules can relieve myocardial infarction induced by ischemia-repeffusion in rats.

关 键 词：融斑通脉颗粒 心肌梗死 大鼠 

分 类 号：R285.5[医药卫生—中药学]