加巴喷丁治疗痛性糖尿病神经病变疗效观察  

Effects of gabapentin on painful diabetic neuropathy

作　　者：姜宏卫[1] 滕中杰[1] 马瑜瑾[1] 李利平[1] 付留俊[1] 刘婕[1] 宋白利[1] 

机构地区：[1]河南科技大学第一附属医院内分泌科,洛阳471003

出　　处：《中国实用医刊》2008年第21期16-17,共2页Chinese Journal of Practical Medicine

摘　　要：目的观察对甲钴胺治疗痛性糖尿病神经病变效果欠佳者，给予加巴喷丁治疗是否可进一步改善症状。方法经甲钴胺治疗3周的49例痛性糖尿病神经病变患者随机分为两组：对照组仍给予甲钴胺片500μg／次，每日3次，口服；治疗组在口服甲钴胺片的同时，给予加巴喷丁，300mg／d起始，酌情调整剂量，直至2700mg／d。两组疗程均为6周。主要疗效指标为数字强度分级法评价疼痛强度。结果经过6周治疗，两组患者的疼痛症状均有改善。加巴喷丁组有效率为59．1％，显效率为13．6％，总有效率为72．7％，显著高于对照组（总有效率42．9％，X^2=3．9389，P=0．0472）。结论对于甲钴胺治疗效果欠佳的痛性糖尿病神经病变患者，加巴喷丁有较好疗效，疗效优于继续使用甲钴胺。Objective To observe the effect of the gabapentin on painful diabetic neuropathy （PDN） in patients who were not satisfied with effect of mecobalamine. Methods A total of 49 PDN cases, who were not satisfied with 3 weeks treatment of mecobalamine, were at random divided into two groups. They were given the drug of mecobalamine tablet （ control group, n = 23 ）, or gabapentin （titrated from 300 mg/d to 2700 mg/d, or maximum tolerated dosage ） combined with mecobalamin （therapeutic group, n =26）. Results After 6 weeks＇ therapy, the efficacy rate was 72.7% in gabapentin group, and 42.9% in control group. The improvement of PDN symptoms in the gabapentin therapeutic group was significantly better than that of the control group （ X^2=3.9389, P=0.0472）. Conclusion Gabapentin have good effects on PDN symptoms in patients who were not satisfied with effect of mecobalamine.

关 键 词：加巴喷丁 甲钴胺 痛性糖尿病神经病变 

分 类 号：R587.2[医药卫生—内分泌]