芪苈强心胶囊对慢性心力衰竭患者血管内皮功能的影响  

Effects of"Qili Qiangxin Capsule"on Endothelial Function in Patients with Chronic Heart Failure

作　　者：马芳放[1] 路凤月[1] 赵振军[1] 王庆利[1] 冯书文[1] 

机构地区：[1]河北医科大学附属以岭医院心内科,河北石家庄050091

出　　处：《上海中医药杂志》2008年第10期18-20,共3页Shanghai Journal of Traditional Chinese Medicine

基　　金：河北省中医药管理局基金资助项目(062761791)

摘　　要：目的观察芪苈强心胶囊对慢性心力衰竭(CHF)患者内皮功能及心功能的影响。方法将120例CHF患者随机分为2组。治疗组(60例)给予常规抗心衰治疗加口服芪苈强心胶囊2～4粒,3次/d;对照组(60例)给予常规抗心衰治疗加口服卡托普利12.5～25mg,3次/d。两组均治疗4周,观察治疗前后一氧化氮(NO)、内皮素(ET)、降钙素基因相关肽(CGRP)及肱动脉血管舒张功能和心功能的变化。结果治疗后两组血NO、CGRP水平均上升,ET下降(P<0.01);治疗组治疗后肱动脉流量介导性舒张(FMD)活性显著增强,与对照组比较有显著差异(P<0.01)。两组治疗后左室功能各指标EF、E峰、A峰与E/A与治疗前比较差异均具统计学意义(P<0.05,P<0.01);治疗后治疗组EF、E峰与E/A较对照组高,差异具统计学意义(P<0.05);治疗组心衰疗效优于对照组(P<0.05)。结论芪苈强心胶囊对CHF具有良好的治疗作用,其作用机制可能与改善血管内皮功能有关。Objective To evaluate the effects of ＂Qili Qiangxin Capsule＂（QLQX） on endothelial function and cardiac function in patients with chronic heart failure （CHF）. Methods One hundred and twenty patients were randomly divided into two groups. Sixty patients in treatment group were treated with QLQX combined with conventional western medical therapy, and 60 patients in the control group received conventional therapy concluding captopril, both for 4 weeks. The levels of nitric oxide （NO）, endothelin （ET）, calcitonin gene-related peptide （CGRP） in plasma, vasodilation of brachial artery and cardiac function were observed before and after treatment. Results ①The levels of NO and CGRP were raised and the level of ET was decreased in both groups, and were more remarkable in treatment group than in control group（P〈 0.01）.②The activity of flow-mediated dilation（FMD） of brachial artery and left ventricular ejection fraction（LVEF） were significantly strengthened in the treatment group, which was remarkably different from that of the control group（P〈 0.01）. Conclusion QLQX has a good therapeutic effect in patients with CHF, which may beassociated with the improvement of vascular endothelial function.

关 键 词：慢性心力衰竭 芪苈强心胶囊 血管内皮功能 心功能 

分 类 号：R259[医药卫生—中西医结合]