凋亡相关基因Bcl-2、Caspase-3与妊娠高血压疾病  

The expression of Bcl-2, Caspase-3 in placenta tissue of hypertensive disorder complicating pregnancy

作　　者：徐晓红[1] 颜涛玲[1] 董绍萍[1] 滕红[2] 

机构地区：[1]厦门市第二医院妇产科,361021 [2]吉林大学第二医院妇产科,长春130041

出　　处：《中国医师进修杂志》2008年第10期1-3,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的 探讨妊娠高血压疾病（HDCP）产妇胎盘组织凋亡相关基因Bcl-2和Caspase-3的表达及其相关性。方法应用免疫组织化学S-P法检测51例轻度子痫前期（轻度组）、50例重度子痫前期（重度组）及62例正常晚期妊娠（对照组）产妇胎盘组织Bcl-2和Caspase-3的表达情况。结果Bcl-2阳性率三组比较差异无统计学意义。Caspase-3阳性率在轻度组（53％）、重度组（64％）显著高于对照组（23％）。Bcl-2与Caspase-3在HDCP产妇胎盘组织中的表达呈负相关（r=-0．199，P〈0．05）。结论在HDCP产妇胎盘组织中Caspase-3表达上调、Bel-2表达无明显变化。HDCP的发病机制可能与Caspase-3表达变化有关。Objective To investigate the expression of Bel-2 and Caspase-3 in placenta tissue of hypertensive disorder complicating pregnancy （HDCP）. Methods One hundred and one placentas with preeclampsia （including 51 mild preeclampsia and 50 severe preeclampsia respectively served as low-grade group and high-grade group） and 62 placentas of normal late pregnant women（served as control group） were analyzed for the expressions of Caspase-3 and Bel-2 using immunohistoehemistry assay （streptavidin-biotin peroxidase method）. Results The positive expression ratio of Bel-2 was 66% in high-grade group, 75% in low-grade group and 84% in control group. There was no significant difference among the three groups （P〉 0.05）. The positive expression rates of Caspase-3 in high-grade group （64%） and low-grade group （53%） were significantly higher than that in control group （23%）（P 〈 0.01 ）. There was no significant difference between high-grade group and low-grade group （P 〉 0.05）. Negative relationship between the expression of Bcl-2 and Caspase-3 could be found with statistical significance （r =-0.199, P 〈0.05）. Conclusions Higher expression of Caspase-3 maybe play an important role in the pathogenesis of HDCP. The role of Bcl-2 in HDCP needs to be studied.

关 键 词：高血压 妊娠性 细胞凋亡 基因 

分 类 号：R714.246[医药卫生—妇产科学]