海洋溶菌酶膜剂治疗细菌性阴道病疗效观察  

Study on the efficacy of marine lysozyme film in treatment of bacterial vaginitis

作　　者：兰晓明 刘静[2] 郭新华[3] 戴红英[3] 王春波[3] 

机构地区：[1]青岛卫生学校,山东青岛266071 [2]山东省人口和计划生育委员会 [3]青岛大学医学院

出　　处：《中国妇幼保健》2008年第30期4345-4346,共2页Maternal and Child Health Care of China

基　　金：国家自然科学基金863计划资助项目(2003AA625070);山东省科技厅资助项目(22130107)

摘　　要：目的:观察海洋溶菌酶膜剂(商品名:海妇洁膜)治疗细菌性阴道病的疗效。方法:将收治的细菌性阴道病患者,经微生物学检查未合并其他阴道炎者300例,随机分为两组,研究组150例,用海妇洁膜治疗,对照组150例,用甲硝唑泡藤片治疗。观察并比较两组治疗结束后3天的有效率和不良反应,于下次月经干净后复查各组的复发率。结果:研究组有效率为96%,对照组为78%,复查复发率:研究组为8.03%,对照组20.93%,两组比较,差别有显著性意义(P<0.01)。另外,研究组未出现不良反应,对照组有36例(24.00%)患者在用药期间有阴道烧灼感,41例(27.33%)患者反映阴道分泌物多。结论:海妇洁膜治疗细菌性阴道病疗效肯定,复发率低,安全性高。Objective： To evaluate the efficacy of marine lysozyme film in treatment of bacterial vaginitis. Methods： 300 patients without any other kind of vaginitis were randomly and evenly assigned to receive marine lysozyme film either every other day intotal of 7 times or metronidaxole vaginaal effervescent tablets （ 150 in treatment group and 150 in metronidaxole group） . Clinical efficacy and adverse reactions were assessed 3 days after the treatment, and recurrence was checked after the next menstruation. Results： There was tatistically significant difference （P 〈 0. 01 ） between the treatment group and metronidaxole group in both clinical efficacy and recurrence of the disease. The efficacy rate for clinical symptoms were 96 % and 78% respectively. The recurrence were 8.03 % and 20. 93 % respectively. Moreover, there was no adverse reaction in patients treated with marine lysozyme , while affected parts of 24% patients of the metronidaxole group （36 cases） were cauterized and secretion of 27. 33% patients （41 cases ） were increased. Conclusion： Treatment with marine lysozyme film for patients with bacterial vaginitis is well tolerated with demonstated efficacy and safety profile.

关 键 词：海洋溶菌酶 膜剂 细菌性阴道病 

分 类 号：R711.31[医药卫生—妇产科学]