肥胖儿童血脂、载脂蛋白与心血管疾病的关系  

Relationships between Serum Lipid,Apolipoproteins and Angiocardiopathy in Obese Children

作　　者：李时莲[1] 张美和[2] 宋文琪[2] 靳剑云[2] 赵秋虹[3] 余焕玲[4] 

机构地区：[1]首都医科大学附属北京儿童医院营养研究室,北京100045 [2]首都医科大学附属北京儿童医院检验中心,北京100045 [3]首都医科大学附属北京儿童医院免疫研究室,北京100045 [4]首都医科大学营养与食品卫生学系,北京100069

出　　处：《实用儿科临床杂志》2008年第19期1494-1495,1498,共3页Journal of Applied Clinical Pediatrics

摘　　要：目的分析肥胖儿童血脂状况,了解其与心血管疾病的关系。方法收集首都医科大学附属北京儿童医院营养门诊就诊的4～16岁的肥胖儿童153例。男109例,女44例;年龄4～16岁。用电阻抗法测量和计算其体脂肪率、体脂肪量、除脂肪量。用软皮尺测量其腰围和臀围,公式计算腰臀比值。用皮褶计测量其肩胛骨下、肱三头肌皮褶厚度,公式计算其肩胛骨下肱三头肌皮褶厚度比值。同时进行其血清胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、载脂蛋白AⅠ和载脂蛋白B(ApoB)水平检测。应用SPSS11.0软件进行统计学分析。结果与心血管疾病相关的指标:高TC发生率为3.3%,高水平LDL-C发生率为6.0%,高TG发生率为24.7%,低水平HDL-C发生率为31.3%。10岁以上肥胖儿童体质量比率、体脂肪率与HDL-C水平呈弱负相关(r=-0.202,-0.211)。结论肥胖儿童血脂和载脂蛋白水平可评估心血管疾病危险因素。Objective Te analyze obese children sermn lipid level in order to understand the relationship between serum lipid and cardiovascular disease in obese children. Methods One hundred and fifty - three children （ 109 male and 44 female ） aged 4 - 16 years oht with obesity who attended the outpatient clinic of Beijing Children＇s Hospital were collected. Percentage body fat （ % BF）, body fat （BF） ,fat - free mass （FFM） was estimated by using bioelectrical impedance analysis （BIA） and calculate. Waist and hip circumference, waist - to - hip ratio （WHR） was estimated by soft tape measure and calculate. Skinfold thickness of scapular bone below （S） and triceps muscle （T） ,S/T rate was estimated by skin fold meter and calculate. Serum total cholesterol （TC） ,triglyceride （TG）, high density lipoprotein （HDL - C ） ,low density lipoprntein （ LDL - C ） , apolipoprotein （Apo） AⅠ and Apo B levels were also measured. SPSS 11. 0 software was used to analyzed the data. Results The cardiovascular disease related was the prevalence of high TC levels（3.3% ）or high LDL- C level（6.0% ） and high TG level （24.7%） was rather low. HDL - C level was reduced in 31.3% of obese children. In ehihlren over 10 years old,% BW and % BF showed a weak correlation with HDL - C（r = - 0. 202, - 0. 211 ）. Conclusions In obese children,serum lipid as well as Apo level should be examined in order to evaluate angiocardiopathy.

关 键 词：肥胖症 血脂 载脂蛋白 心血管疾病 儿童 

分 类 号：R723.14[医药卫生—儿科]