肝病专用肠内营养制剂对肝功能损害患儿蛋白质代谢和肝功能的影响  

Effect of Liver Disease Special-Purpose Enteral Nutrition Preparation on Protein Metabolism and Liver Function in Children with Liver Injury

作　　者：杨军红[1] 田曦[1] 陈颖新[1] 徐宗鲁[1] 赵文卓[1] 林莹[1] 

机构地区：[1]天津市儿童医院营养科,天津300074

出　　处：《实用儿科临床杂志》2008年第19期1518-1519,1550,共3页Journal of Applied Clinical Pediatrics

摘　　要：目的观察含高支链氨基酸的肝病专用肠内营养制剂对重症并肝功能不全患儿肝功能和血清清蛋白水平的影响。方法本院重症并肝功能不全住院患儿60例。男36例,女24例;年龄为(7.8±6.3)岁。随机分为添加肝病专用肠内营养制剂的支持治疗组(治疗组)和整蛋白全营养型肠内营养制剂的支持对照组(对照组),每组各30例。二组均采取鼻饲肠内营养支持,供给热能418～628kJ/(kg.d)。分别于治疗前第1天及治疗后第14天检查二组肝功能,测定其血清清蛋白和Hb等指标。采用SPSS11.5软件进行统计学分析。结果治疗前二组患儿的各项指标测定值相近,治疗14d,治疗组患儿的ALT和AST均较对照组显著降低(Pa<0.05);二组患儿治疗前后血清总蛋白、清蛋白及血红蛋白均显著升高(Pa<0.05),组间比较无显著性差异。结论肝病专用肠内营养制剂对肝功能损害患儿有明显的临床治疗效果。Objective To observe the effect of liver disease special - purpose enteral nutrition preparation on protein metabolism and liver function in children with liver injury. Methods Sixty cases of severe ill with liver injury in hospital ,with mean age of （7.8 ±6.3 ） years old. All patients were randomly divided into experimental group （n=30） and control group（ n =30）. The experimental group was treated by adding the liver disease special - purpose enteral nutrition preparation homogenized diet and control group was treated by adding entire protein entire nutrition type enteral nutrition preparation. All patients in both 2 groups were nasally fed with intestinal nutrition, which contained 418 - 628 k J/（ kg · d）. One day before nutritional support and 14 days after nutritional support, the liver function, total serum protein, albumin, hemoglobin were recorded. SPSS 11.5 software was used to analyze the data. Results The baseline indicators were similar before nutritional supports. Fourteen days after nutritional support,alanine aminotransferase（ALT） and aspartate aminotransferase （AST） were all significantly lower in experimental group than in control group（Pa 〈0.05 ）. Total serum protein,albumin,hemoglobin were all significantly improve before and after treatment in 2 groups （Pa 〈0.05 ） ,however,eomparision between 2 groups such differences had no statistical significance. Conclusion The liver disease special - purpose enteral nutrition preparation have a beneficial effect on children with liver injury.

关 键 词：肠内营养 肝功能不全 支链氨基酸 儿童 

分 类 号：R725.7[医药卫生—儿科]