基因多态性与尘肺病遗传易感性关系研究进展  

Genetic polymorphism and susceptibility to pneumoconioses

作　　者：吴芬[1] 夏昭林[1] 

机构地区：[1]复旦大学公共卫生学院劳动卫生学教研室与教育部公共卫生安全重点实验室,上海200032

出　　处：《中国工业医学杂志》2008年第5期309-311,318,共4页Chinese Journal of Industrial Medicine

摘　　要：矽肺和煤工尘肺(CWP)是尘肺病最常见、影响最广泛的两种类型,其发病取决于粉尘暴露量及个体易感性。基因多态性是影响个体易感性的主要因素。本文对尘肺病发生发展与基因多态性关系的研究进展作一综述,作为个体易感性研究的重要基础。Silicosis and coal worker＇s pneumoconioses （CWP） are two most popular and impactive types of pneumoconioses in China. The development both of silicosis and CWP mainly depends on dust exposure level and individual susceptibility, while genetic polymorphism is the principal factor in affecting individual susceptibility. In order to provide some important data for the research on those fields mentioned above, the progress on the relationship between genetic polymorphism and development of these pneumoconioses was summarized in this paper.

关 键 词：矽肺 煤工尘肺 基因多态性 细胞因子 组织相容性白细胞抗原 抗氧化酶 

分 类 号：R135.2[医药卫生—劳动卫生]