临床前列腺癌病理分级系统应用于基因敲入和转基因小鼠前列腺癌模型研究  

Study on human histopathology grading system in a transgenic and knock-in mouse prostate cancer model

作　　者：武国军[1] 李晓武[1] 朱李兵[1] 王禾[1] 袁建林[1] 张更[1] 于磊[1] 王立国[1] 刘贺亮[1] 

机构地区：[1]第四军医大学西京医院泌尿外科,西安710032

出　　处：《山西医科大学学报》2008年第10期889-892,共4页Journal of Shanxi Medical University

基　　金：军队医药卫生"十一五"科研基金资助项目(06H040);第四军医大学优秀博士学位论文课题基金资助项目

摘　　要：目的利用临床前列腺癌Gleason病理分级系统分析比较基因敲入(KIMAP)和转基因(TGMAP)小鼠前列腺癌模型。方法依照前列腺癌临床诊断的Gleason五级10分制的组织学分级和评分标准,对96例KIMAP和44例TGMAP前列腺癌标本进行了分析,并与临床前列腺癌进行了比较。结果KIMAP的组织学评分分布在4-9范围内,而TGMAP组织学评分全部分布在高数值范围内(6-10)。KIMAP小鼠(52.1%)比TGMAP小鼠(25.0%)表现出更高的混合组织学评分率,更接近于临床平均值(50.0%)。结论由于KIMAP模型成功地模仿了人类前列腺癌特征,在前列腺癌临床前期研究中具有潜在的应用价值。Objective To compare the new knock-in mouse adenocarcinoma prostate model（KIMAP）with transgenic mouse adeno- carcinoma prostate model（TGMAP）and human prostate cancer（CaP）using human Gleason grading system. Methods Ninty-six cases of KIMAP and 44 cases of TGMAP prostate cancer samples were measured and compared with human CaP according to hetero- geneity of the clinical standard for prostate cancer diagnosis. Results The Glcason score was 4 - 9 for KIMAP and 6 - 10 for TGMAP. KIMAP mice showed a higher percentage （52. 1% ）of compound histological score rate than that of TGMAP mice （25.0 % ）, but closer to the clinical average（50.0 % ）. Conclusion The result indicates that KIMAP model can be applied in the clinical study of human CaP due to its effective mimicry of human CaP tumors.

关 键 词：前列腺肿瘤 动物模型 小鼠 

分 类 号：R392.11[医药卫生—免疫学]