苦参碱对急性心肌缺血大鼠血流动力学的影响  

Effects of Matrine on the Hemodynamics in Rats of Acute Myocardial Ischemic Injury

作　　者：聂黎虹[1] 赵瑞宁[2] 丁娟[1] 彭涛[1] 周永忠[1] 周旭[1] 

机构地区：[1]宁夏医学院基础学院生理学教研室,银川750004 [2]宁夏医学院附属医院泌尿外科,银川750004

出　　处：《宁夏医学院学报》2008年第5期556-558,共3页Journal of Ningxia Medical College

基　　金：宁夏医学院面上项目

摘　　要：目的研究苦参碱对急性心肌缺血大鼠血流动力学的影响。方法将SD大鼠随机分为8组:正常对照组,假手术组,模型组,丹参组,硝酸甘油组,苦参碱2.5、5、10mg/kg剂量组。应用左冠状动脉前降支(LAD)结扎法制备大鼠急性心肌缺血模型,记录结扎前、结扎后5、15、30和60min大鼠左心室收缩压(LVSP)、左心室终末舒张压(LVEDP)、左心室内压最大上升速率(+dp/dtmax)和左心室内压最大下降速率(-dp/dtmax)等指标。结果与对照组和假手术组比较,左冠状动脉前降支结扎后5、15、30,60min,模型组大鼠LVSP、+dp/dtmax、-dp/dtmax明显降低(P<0.05或P<0.01),LVEDP明显升高(P<0.01)。与模型组比较,左冠状动脉前降支结扎后5、15、30、60min,静脉注射苦参碱2.5、5和10mg/kg均可使大鼠LVSP、+dp/dtmax、-dp/dtmax明显升高(P<0.05或P<0.01),LVEDP明显降低(P<0.05或P<0.01)。此作用在左冠状动脉前降支结扎后15、30min最明显,且随着药物剂量增加,药物作用时间延长。结论静脉注射苦参碱可改善急性心肌缺血大鼠的心功能。Objective To study the effects of matrine on the hemodynamics in Rats of Acute Myocardial Ischemic Injury. Methods Sprague- Dawley rats were divided into eight groups, i. e., control, sham operation, AMI, Danshen ＋ AMI, nitroglycerin ＋ AMI, AMI ＋ MT2.5mg/kg, 5mg/kg, or 10mg/kg. Rat models of AMI were created by ligation left anterior descending coronary artery. At pre- occlusion and 5,15,30,60 min after left anterior descending artery（LAD） occlusion, left ventricular systolic pressure（LVSP）, left ventricular end diastolic pressure（LVEDP）, ＋ dp/dtmax and - dp/dtmax were measured. Results At 5,15,30,60 rain after left anterior descending artery occlusion, LVSP, ＋ dp/dtmax, - dp/dtmax were reduced（ P 〈 0.05 or P 〈 0.01 ）and LVEDP was increased significantly（ P 〈 0.01 ）in AM! group. At 5, 15,30, 60 rain after LAD occlusion, LVSP, ＋ dp/dtmax, - dp/dtmax were increased（ P 〈 0.05 or P 〈 0.01 ）and LVEDP was reduced significantly（ P 〈 0.05 or P 〈 0.01 ）in AMI rats after MT administration at the dosage of 2.5 mg/kg, 5 mg/kg, 10 mg/kg. At 15,30 rain after LAD occlusion, this function was obvious. The more rats got matrine, the longer the changes of parameters mentioned above lasted. Conclusion Intravenous matrine can improve the cardiac function.

关 键 词：苦参碱 血流动力学 急性心肌缺血 大鼠 

分 类 号：R285.5[医药卫生—中药学]