硝苯地平延迟起释型缓释片的制备及体外释放  

Preparation and in vitro release of nifedipine delayed-onset sustained-release tablets

作　　者：杜璇[1,2] 屠锡德[1] 周建平[1] 

机构地区：[1]中国药科大学药剂学教研室,南京210009 [2]上海市中医药科技产业促进中心,上海201203

出　　处：《中国药科大学学报》2008年第5期412-416,共5页Journal of China Pharmaceutical University

摘　　要：目的:制备符合时辰药理学的硝苯地平缓释片。方法:用粉末直接压片法制备片芯,干压包衣技术制备缓释片。正交试验优选处方,对最优处方进行体外释放度验证。结果:脉冲缓释片延迟时间约5～6h,释放机制以骨架溶蚀起主导作用。结论:硝苯地平延迟起释型缓释片处方设计和工艺方法可行,质量稳定。Aim： To explore the preparation methods of nifedipine delayed-onset sustained-release tablets in accordance with ehronopharmaeology. Methods： Delayed-onset sustained-release tablets were prepared by direct compression of the powder mixture containing insoluble materials and coated using dry powder coating. The formulation was optimized by using the orthogonal design. Results： The lag time of the tablets was about 5-6 h. It was indicated that matrix erosion attribute to the major mechanism in the tablets release. Conclusion： We obtain the practical formulation and manufacturing processing of nifedipine delayed-onset sustained-release tablets and the tablet quality is stable.

关 键 词：硝苯地平 延迟起释型缓释片 口服择时释药系统 体外释放 

分 类 号：R944[医药卫生—药剂学]