微波辅助离子液体中3-(甲氧基羰基甲基)替加氟的合成  

Synthesis of 3-(Methyloxycarbonyl) Tegafur Assisted by Microwave Irradiation in Ionic Liquid

作　　者：徐绍红[1] 张伟[1] 

机构地区：[1]新乡学院,河南新乡453003

出　　处：《化学与生物工程》2008年第10期18-20,共3页Chemistry & Bioengineering

摘　　要：以氯乙酸和甲醇为原料,在无溶剂和250 W微波辐射10 min条件下,合成了氯乙酸甲酯,产率91.0%;随后以[bmim]BF4为溶剂,在250 W微波辐射18 min条件下,与替加氟反应,快速合成了3-(甲氧基羰基甲基)替加氟,产率82.3%。产物结构经IR1、HNMR和HRMS表征。Methyl chloroacetate was synthesized from chloroaeetic acid and methanol at solvent-free condition under microwave irradiation at 250 W for 10 min,and the yield was up to 91.0%. Then,using [bmim] BF4 as solvent,3-（methyloxycarbonyl） tegafur was synthesized from tegafur and methyl chloroacetate under microwave irradiation at 250 W for 18 min, and the yield was up to 82.3%. The compounds were characterized by IR,^1 HNMR, HRMS.

关 键 词：离子液体 微波辐射 3-(甲氧基羰基甲基)替加氟 氯乙酸甲酯 合成 

分 类 号：O623.624[理学—有机化学]