2,5-二(4-羧基苯基)-1,3,4-噁二唑的改进合成  

Modified synthesis of 2,5-bis(4-carboxyphenyl)-1,3,4-oxadiazole

作　　者：杨捷[1] 包魏魏[1] 张海娟[1] 沈旋[1] 朱敦如[1] 

机构地区：[1]南京工业大学化学化工学院,江苏南京210009

出　　处：《南京工业大学学报（自然科学版）》2008年第5期20-23,共4页Journal of Nanjing Tech University(Natural Science Edition)

基　　金：国家自然科学基金资助项目(20771059);江苏省自然科学基金资助项目

摘　　要：为了制备纳米多孔配位聚合物,常选择取代的芳香羧酸类化合物作为刚性的桥联配体.设计了一条改进的合成路线来制备芳香羧酸类配体2,5-二(4-羧基苯基)-1,3,4-噁二唑,以4-甲基苯甲酸为原料,通过肼解关环和KMnO4氧化二步反应最终合成了2,5-二(4-羧基苯基)-1,3,4-噁二唑,产率为82%.产物经元素分析、红外光谱和核磁共振谱表征.与以往的合成路线相比,本方法步骤更简单,产率更高.In order to prepare nanoporous coordination polymers, substituted aromatic dicarboxylate compounds are often selected as rigid bridge-linking ligands. A modified synthetic route was designed for preparing an aromatic di- earboxylate ligand： 2,5-bis（4-earboxyphenyl）-1,3,4-oxadiazole. By using 4-methylbenzoic acid as a starting material, the ligand was synthesized successfully in 82% yield by the two-step reactions （hydrazinolysis cyclization and oxidation using KMnO4 ） and characterized by elemental analysis, FT-IR, NMR spectra. The method has less steps and higher yield compared with the synthetic routes.

关 键 词：合成 表征 2 5-二(4-羧基苯基)-1 3 4-噁二唑 

分 类 号：O623.65[理学—有机化学]