消抗灵Ⅱ号对小鼠解脲支原体感染及感染后血清中干扰素-γ的影响  

Effect of XiaokanglingⅡon Ureaplasma Urealyticum Infected Mice and Their Serum IFN-γ

作　　者：韩延华[1] 辛雪艳[1] 

机构地区：[1]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040

出　　处：《世界中西医结合杂志》2008年第2期83-85,共3页World Journal of Integrated Traditional and Western Medicine

基　　金：黑龙江教育厅基金资助项目

摘　　要：目的:探讨消抗灵Ⅱ号对雌性小鼠解脲支原体(Uu)感染的治疗作用及对感染后血清干扰素-γ(IFN-γ)的影响。方法:取8￣10周龄BALB/c雌性小鼠80只,按1∶3的比例随机分为健康对照组(简称对照组)和造模组,造模组造模成功后按1∶1∶1比例随机分为中药组、西药组、模型组,分别给予消抗灵Ⅱ号、阿奇霉素、生理盐水灌胃,2w后取小鼠阴道分泌物检测Uu感染生长变化,采小鼠眼球血测血清IFN-γ水平。结果:中药组的Uu转阴率(95%)高于西药组(60%),有显著性差异(P<0.05)。血清IFN-γ水平中药组分别与西药组、模型组比较,有极显著性差异(P<0.01),中药组与对照组相比,无显著性差异(P>0.05),西药组分别与模型组、对照组相比,有极显著性差异(P<0.01)。结论:消抗灵Ⅱ号能消除解脲支原体,治疗Uu感染,其治疗作用可能是通过降低血清中IFN-γ的水平而实现的。Objective：To study the effect of Xiaokangling Ⅱ （XKL Ⅱ ）on Ureaplasma urealyticum（Uu）infected mice and their serum IFN-γ. Methods：20 female BALB/e mice of 8-10 weeks old were randomly divided into control group and Uu infected group by 1：3. The mice in the Uu infected group were randomly divided into XKL Ⅱ group, azitromycin group, and saline group by 1：1：1. The changes of Uu in mice vagina and the level of IFN-γ in serum were determined two weeks later. Results：95% of Uu infection turned negative in XKL Ⅱ group,which is significantly higher than that （60%）of azitromyein group （P〈0.05）. Serum IFN-γ of XKL Ⅱ group was significantly different from that of azitromyein group and saline group（P〈0.01）. There is no significant difference of IFN-γ between XKL Ⅱ group and control group（P〉0.05）. The IFN-γ of azitromyein group was significant different from saline group and control group （P〈0.01）. Conclusion：XKL Ⅱ might reduce the serum IFN-γ to remove Uu and treat the infection.

关 键 词：解脲支原体 消抗灵Ⅱ号 干扰素-Γ 

分 类 号：R285.5[医药卫生—中药学]