绝经后女性冠心病患者雌性激素测定的临床意义  

Changes of Estrogen in Postmenopausal Women with Coronary Artery Disease

作　　者：何学贤[1] 蒋立[2] 

机构地区：[1]解放军第169医院检验科,湖南衡阳421002 [2]解放军第163医院检验科,湖南长沙410003

出　　处：《医学临床研究》2008年第10期1843-1844,共2页Journal of Clinical Research

摘　　要：【目的】探讨绝经后女性雌性激素的变化及其与冠心病的关系。【方法】采用微粒子化学发光免疫分析技术测定48例绝经后女性冠心病患者和40例正常对照组血清雌二醇(E2)、孕酮(P)、催乳素(PRL)、促卵泡激素(FSH)、促黄体激素(LH),并进行显著性检验。【结果】绝经后女性冠心病患者组较对照组的E2明显降低,差异具有显著性(P<0.01),其余差异均无显著性(P>0.05)。【结论】绝经后女性冠心病患者E2水平明显减低,它与动脉粥样硬化之间存在一定的相关性。[Objective]To investigate the changes of estrogen in the blood in postmenopausal women with coronary heart disease （ CHD ）. [Methods] Serum eslradiol （E2）, progesterone （P）, follicle stimulating hor mone （FSH）, luteinizing hormone （LH） and prolactin （PRL） in 92 postmenopausal women with CHD and 40 health subjectss as control were measured by mieroparticle chemilumineseence immunoassay. [Results] Compared to controls, serum E2 concentration was significantly lower in postmenopausal women with CHD （ P〈0.01）. [Conclusion]The E2 concentration decreases significantly in postmenopausal women with CHD, and is correlated to atherosclerosis.

关 键 词：冠状动脉疾病 雌激素类/分析 绝经 

分 类 号：R543.3[医药卫生—心血管疾病]