感染性休克急性肺损伤CD11b表达与纤维蛋白原相关性研究  

The study on expression of neutrophils CD11b and fibrinogen in pediatric acute lung injury of septic shock

作　　者：郭景涛[1] 本贵勇[1] 黄义双[1] 黄卫东[1] 刘纯义[1] 陆必森[1] 夏汉兵[1] 

机构地区：[1]广东省深圳市宝安区妇幼保健院,518000

出　　处：《中国临床实用医学》2008年第10期44-45,共2页China Clinical Practical Medicine

摘　　要：目的探讨感染性休克急性肺损伤（ALI）患儿粒细胞表面CD11b表达与纤维蛋白原（FIB）水平的变化及意义。方法用流式细胞术检测感染性休克ALI（观察组）患儿25例中性粒细胞CD11b与纤维蛋白原，并与对照组18例和正常组20例比较。结果在急性期、恢复期，观察组中性粒细胞CD11b，与对照组和正常组比较，P〈0．05。ALI患者外周血纤维蛋白原（FIb）水平，其均值（5．15±1．02）q／L，明显高于正常参考值（3．50q／L），差异有统计学意义（P〈0．01）；恢复期与正常组无显著差异。结论CD11b与纤维蛋白原参与感染性休克ALI病理发展过程，表达水平与预后密切相关。可作为预测肺损伤发展的重要指标。提示给予纤溶治疗可作为一种提高疗效的尝试。Objective To explore significance of expression of neutrophils CD11 b and fibrinogen in pediatric acute lung injury of septic shock. Methods Expression of neutrophils CD11b were measured with flow cytometry and fibrinogen in 25 cases with pediatric acute lung injury, compared with 18 cases of controlling group and 20 cases of normal group. Results In acute and recovery phase,expression of neutrophils CD11b in acute lung injury group were, it is higher than that of controlling group and normal group, P 〈 0. 05, respectively. The mean value of plasma fibrinogen（x ± s,5. 68 ±1.25 g/l） of the acute lung injury cases was higher than the normal value（P 〈 0.01 ）. Compared with recovery group and normal group, There was no significant difference （P 〉 0.05 ）. Conclusion Expression of neutrophils CD11 b and fibrinogen takes a centain effect during the prognosis of pediatric acute lung injury. It can be look upon as judgement of acute lung injury ,predicting the development of disease.

关 键 词：感染性休克 急性肺损伤 CD11B 纤维蛋白原 

分 类 号：R459.7[医药卫生—急诊医学]