生物学标志物CTX-Ⅱ对骨关节炎的诊断价值  

Diagnosis value of biological markers CTX-Ⅱ in osteoarthritis

作　　者：李正南[1] 卫小春[1] 

机构地区：[1]山西医科大学第二附属医院骨科,山西太原030001

出　　处：《中国骨伤》2008年第9期719-722,共4页China Journal of Orthopaedics and Traumatology

基　　金：山西省科技攻关项目(编号2006031089-3)

摘　　要：骨性关节炎早期诊断是医学中的难题,由于疾病发展缓慢,早期往往不引起临床症状,也无X线表现,故传统的诊断方法难以早期诊断,丧失了早期治疗的机会,导致后期治疗效果不佳,甚至有部分患者发展为关节畸形、活动受限,最后采取手术方法治疗,给患者带来极大的痛苦和沉重的经济负担。如何早期诊断关节软骨损伤成为目前OA研究的重点和难点。有学者曾提出对可疑的OA患者可以用关节镜检查诊断,此是最理想的诊断方法,虽然其创伤小、恢复快,但也属于手术方法之一,具有一定的创伤性,这不仅人为增加了患者的痛苦,而且治疗费用昂贵,使绝大多数患者望而却步。国内外学者进行了大量研究,欲在OA患者的体液中寻找理想的生物学标志物(BM)来及时反映关节软骨代谢状态,并揭示病情活动或预后,而CTX-Ⅱ是可反映软骨降解的BM之一。It is very difficult to diagnosis osteoarthritis in the early stage,due to the slow development of the disease,no symptoms occures, and no X-ray findings in the early stage, it is difficult to early diagnosis with the traditional diagnostic methods, resulting in the poor treatment outcome, and even some patients develop joint deformity, activity limitation, and must take an operation, it brought great pain and heavy financial burden to patients. How to early diagnosis of articular cartilage injury become difficult now. Some scholars suggest that to those suspected patients, the arthroscopic diagnosis must be taken.Although the small trauma and quick recover, the method of operation has trauma, not only increase the suffering of the patients, but the treatment is very expensive, make the patients finch. A large number of domestic and foreign scholars to study patients with OA to find the ideal fluid biological markers （BM） to reflect articular cartilage metabolism, and revealed disease activity or prognosis. The CTX- Ⅱ can reflect degradation of the articular cartilage.

关 键 词：骨关节炎 CTX-Ⅱ 软骨 关节 诊断 

分 类 号：R992[医药卫生—毒理学] R735.7[医药卫生—药学]