胃下部癌常规病理阴性第11P组淋巴结微转移的研究  

Lymph node micrometastases in negative no11P lymph nodes by conventional pathology in patients of lower third gastric cancer

作　　者：李宇[1] 周岩冰[1] 李玉军[2] 刘相萍[3] 孙琦[5] 李世宽[4] 徐克锋[1] 

机构地区：[1]山东省青岛大学医学院附属医院普外科,266003 [2]山东省青岛大学医学院附属医院病理科,266003 [3]山东省青岛大学医学院附属医院分子生物学教研室,266003 [4]山东省青岛大学医学院附属医院急诊普外科,266003 [5]上海交通大学医学院小儿外科

出　　处：《中华普通外科杂志》2008年第10期774-776,共3页Chinese Journal of General Surgery

摘　　要：目的检测胃下部癌患者常规病理阴性第11P组淋巴结微转移的情况，分析淋巴结微转移与临床病理因素的关系：方法应用连续切片法和端粒酶重复扩增-ELISA方法检测43例胃下部痛常规病理阴性的43枚第11P组淋巴结，结合临床病理资料进行统计学分析。结果本组43例胃下部癌患者常规病理阴性第11P组淋巴结经连续切片法检出有4例4枚淋巴结发生微转移，微转移发生率为9％；应用端粒酶重复扩增-ELISA法检测微转移发生率为44％，其中包括应用连续切片法检测出有微转移的4枚淋巴结。端粒酶重复扩增-ELISA法微转移检出率明显高于连续切片法（X^2=13．07，P〈0．05）。胃下部癌第11P组淋巴结微转移与原发肿瘤大小（X^2=8．488，P〈0．05）、浸润深度（X^2=6．473，P〈0．05）及临床分期（X^2=12．022，P〈0．05）有关，与患者年龄、性别、大体分型、组织分化程度无关。结论胃下部癌常规病理阴性第11P组淋巴结中存在较高的微转移发生率，其微转移发生率与原发肿瘤大小、浸润深度及临床分期有关。Objective To evaluate the status of lymph node micrometastases in ＂non-metastatic＂ No 11P lymph nodes as judged by conventional pathology in the lower third of gastric cancer. Methods In this study 43 No 11P lymph nodes harvested from 43 patients which was histologically free of metastasis were examined by consecutive sections and TRAP（ telomeric repeat amplification protocol）-ELISA （enzyme linked immunosorbent assay）. The data were statistically analyzed according to the clinicopathological features of the patients. Results Micromctastasis was discovered in 4 lymph nodes from 4 patients by consecutive sections. The micrometastatic rate of the conventional pathologic non-metastatic No 11P lymph nodes was 9%. The micrometastatic rate of the conventional pathologic non-metastasis No 11P lymph nodes detected by TRAP-ELISA was 44% , including 4 lymph nodes observed by consecutive sections It revealed that lymph nodes micrometastases were correlated with the size of the tumor （ X^2 = 8. 488, P 〈 0. 05 ） , and tumor stage （X^2= 12. 022,P 〈 0. 05 ）. It also showed that the micrometastatic rate increased proportionally to tumor infiltration depth（ X^2 =6. 473, P 〈 0. 05） , not correlated with patients＇ demographic features, general type and histological differentiation of the tumor. Conclusions There was a high rate of micrometastasis in No 11P lymph nodes. This lymph nodes micrometastasis was correlated with the size of the tumor, invasion depth of primary tumor and patients＇ clinical stage.

关 键 词：胃肿瘤 肿瘤转移 临床病理学 淋巴结 

分 类 号：R686[医药卫生—骨科学]