高渗盐水在创伤性脑损伤中应用研究  

The research of HTS in traumatic brain injury

作　　者：卫正洪[1] 郑念东[1] 王山[1] 万晓强[1] 

机构地区：[1]乐山市人民医院神经外科,四川乐山614000

出　　处：《现代医药卫生》2008年第22期3328-3329,共2页Journal of Modern Medicine & Health

摘　　要：目的:探讨创伤性脑损伤早期应用高渗盐水(HTS),对继发性脑损害的作用和影响。方法:采用Feeney自由落体损伤兔模型,于伤后早期(伤后3小时)按实验分组不同,经兔耳缘静脉给以不同剂量的7.5%高渗盐水及生理盐水。实验动物于伤后6小时处死,通过比较几组实验动物创伤区域白细胞计数,来说明高渗盐水对继发性脑损害的影响。结果:创伤区域白细胞计数:HTS组的创伤区域的白细胞数较生理盐水组明显减少,差异有显著性(P<0.05);其中4 ml/kg组与6 ml/kg组比较差异无显著性(P>0.05);而二者均较2 ml/kg组低,差异有显著性(P<0.05);与正常组及假手术组比较则明显增加(P<0.05)。结论:高渗盐水具有抑制创伤区域白细胞聚集的作用。Objective：To investigate the effect of early administration of HTS on secondary brain lesion in the treatment of traumatic brain injury,so as to provide a theoretical basis for this therapy.Methods：The lesion model of rabbit was induced by the mode of Feeney＇s freely falling body.Then these animals were divided into 6 groups according to the experimental condition and immediately received intravenously different dosages of either HIS or normal saline.All animals were killed in 6 hours after injury,the leukocyte counts in the traumatic area in 6 groups were compared,so as to show the effect of HIS on secondary brain lesion.Results：The leukocyte count in the traumatic area showed that it was significant decreased compared with that in 0.9% saline group, with a significant difference between them （P〈0.05）;in which,there was significant difference in leukocyte count between 4 ml/kg group and 6 ml group,but both in two groups were lower than that in 2 ml/kg group,with significant difference （P〈0.05）;it was obviously increased compared with that in the normal or pseudoperative group（P〈0.05）.Conclusion：HTS possesses the prohibitory leukocyte aggregation in traumatic areas.

关 键 词：高渗盐水 创伤性脑损伤 继发性脑损害 

分 类 号：R6[医药卫生—外科学]