CYP4F2基因单核苷酸多态性与日本心肌梗死的相关性研究  

Associated study between the polymorphism of the CYP4F2 gene and myocardial infarction in Japanese

作　　者：付真彦[1] 马依彤[1] 杨毅宁[1] 张建发[1] 谢翔[1] 王迎洪[1] 中山智祥 佐藤直之 菅间薰 

机构地区：[1]新疆医科大学第一附属医院心脏中心,新疆乌鲁木齐830011 [2]日本大学医学部先端医学讲座分子诊断学部门,东京1738610

出　　处：《新疆医科大学学报》2008年第9期1119-1123,共5页Journal of Xinjiang Medical University

摘　　要：目的:研究在日本不同性别中,CYP4F2基因单核苷酸多态性与心肌梗死的关系。方法:234例心肌梗死患者和248例年龄匹配的对照分别分为整体组,男性组,女性组。选择CYPF2基因的5个SNPs(rs3093105、rs3093135、rs1558139、rs2108622、rs3093200),应用TaqMan SNP基因分型的方法进行基因分型,并应用病例对照分析的方法进行相关性研究。结果:对于男性,心肌梗死患者rs2108622的G等位基因频率远远高于对照(P=0.001)。结论:CYP4F2基因rs2108622的G等位基因与日本男性心肌梗死相关,可做为日本男性心肌梗死的易感基因标记。Obejective：The aim of the present study was to assess the association between the human CYP4F2 gene and myocardial infarction（MI）in Japanese,using a case-control study with a separate analysis of the gender groups.Methods：There were 234 MI patients and 248 control subjects genotyped for 5 SNPs of the human CYP4F2 gene（rs3093105,rs3093135,rs1558139,rs2108622,rs3093200）.The data were assessed for 3 separate groups：thetotal subjects,men and women.Results：For men subjects,G allele of rs2108622 was significantly higher in the MI patients than the control subjects（P=0.001）.Conclusions：The present results indicate that MI is associated with the G allele of rs2108622 in Japanese men and appears to be a useful genetic marker of EH in Japanese men.

关 键 词：CYP4F2 单核苷酸多态性 心肌梗死 

分 类 号：R473.5[医药卫生—护理学] R394[医药卫生—临床医学]