宫颈薄层液基细胞学检查(LCT)在宫颈癌前病变早期筛查中的临床应用  

Value of liquid-based cytology (Autcyte Prep) in the screening for cervical intraepithelial neoplasia (CIN)

作　　者：王莉[1] 丁岩[1] 殷红莉[2] 耿英[2] 

机构地区：[1]新疆医科大学第一附属医院妇科,新疆乌鲁木齐830011 [2]新疆昌吉州人民医院妇产科,新疆昌吉831100

出　　处：《新疆医科大学学报》2008年第9期1259-1262,共4页Journal of Xinjiang Medical University

摘　　要：目的:评价宫颈薄层液基细胞学检查在宫颈病变早期筛查中的应用价值。方法:选取就诊昌吉州人民医院行宫颈薄层液基细胞学检查(LCT)的530例患者,对细胞学阳性患者或细胞学虽阴性临床高度可疑患者共101例行阴道镜检查,同时镜下定位活检。以病理结果作为金标准,评价宫颈薄层液基细胞学检查(LCT)在临床的应用价值。结果:530例患者采用TBS分类,共检出阳性涂片61例,占11.51%,其中不典型鳞状上皮细胞(AS-CUS)35例(6.6%);不典型腺细胞(AGC)3例(0.57%);低度鳞状上皮内病变(LSIL)15例(2.83%);高度鳞状上皮内病变(HSIL)5例(0.94%);鳞状细胞癌(SCC)3例(0.57%);腺癌(AC)1例(0.19%)。细胞学与阴道镜下活组织病理诊断符合率分别为LSIL:60%(9/15),HSIL:80%(4/5),SCC100%(3/3)。结论:采用LCT检查可以提高宫颈病变的阳性诊断率,细胞学阳性或临床可疑患者应配合阴道镜检查及镜下活检进一步明确诊断及治疗,重视宫颈病变的规范化筛查。Objective： To evaluate the value of liquid-based cytololgy test （Autocyte Prep） in the screening for cervical intraepithelial neoplasia （CIN）. Methods： Form May 2006 to February 2007 ~ 530 cases were detected by liquid-based cytology test （Autocyte Perp）, the positive results or the negative but highly suspected were detected with colposcope and taken cervical biopsy under guidance of Colposcopic for pathological examination. To Campare cytological results with paghlolgical results, and evaluate the value of liquidbased cytololgy test （Autocyte Prep）. Results： The cytological diagnosis criteria were based on the Bethesda System. The positive cases were 61（11.51%）, among them, atypical squamous cells of undetermined significance （ASCUS） were 35 cases （6.6%）, atypical gland cell （AGC） were 3 cases （0. 57%）, low grade squamous intraepithelial lesion （LSIL） were 15 cases （2.83%）, high grade squamous intraepithelial lesion （HSIL） were 5 cases （0.94%）, squamous cell carcinoma （SCC） were 3 cases （0.57）, adeno cell carcinoma （ACC） was 1 case （0.19%）. The ratio of Consistent results between cytology and pathology was： LSIL： 60%（9/15） HSIL： 80%（4/5）, SCC 100%（3/3）. Conclusions： liquid-based cytololgy test （Autoeyte Prep） can improve the positive of cervical intraepithelial neoplasia （CIN）, the positive or the negative but highly suspected should be detected with colposcope and taken cervical biopsy under guidance of colposcopic for pathological examination, we should pay attention to the standardized screening of CIN .

关 键 词：薄层液基细胞学检查(LCT) 宫颈病变 早期筛查 

分 类 号：R446.139[医药卫生—诊断学] R737.33[医药卫生—临床医学]