糖尿病性认知功能障碍：一个不容忽视的问题  

Diabetes associated cognitive impairment： a problem should not be ignored

作　　者：苏杰英[1] 李宏亮[1] 杨文英[1] 

机构地区：[1]卫生部中日友好医院内分泌科,北京100029

出　　处：《中华内分泌代谢杂志》2008年第5期476-479,共4页Chinese Journal of Endocrinology and Metabolism

摘　　要：糖尿病对脑部结构功能有多方面影响，但糖尿病引发的认知功能障碍却常常被忽视。糖尿病性认知功能障碍的发生机制十分复杂，其中糖脂毒性、胰岛素抵抗、低血糖及Ca^2＋稳态被破坏等可能起重要作用。除糖尿病常规治疗方案外，糖尿病性认知功能障碍尚需要探索更加有效的治疗措施。Diabetes can affect structure and function of brain in several aspects, but diabetic cognitive impairment is often ignored. The pathogenesis of diabetes associated cognitive impairment is complicated. Factors such as glucotoxicity, lipotoxicity, insulin resistance, hypoglycaemia and disturbance of Ca^2＋ homeostasis may play important roles. Besides conventional diabetes therapy, new methods still need to be explored.

关 键 词：糖尿病 认知功能障碍 糖毒性 脂毒性 

分 类 号：R587.2[医药卫生—内分泌] R749.2[医药卫生—内科学]