肥胖对2型糖尿病一级亲属胰岛素抵抗、β细胞功能和超敏C反应蛋白水平的影响  

Effects of obesity on insulin resistance, 15-cell function and serum high-sensitivity C-reactive protein level in first-degree relatives of type 2 diabetic patients

作　　者：陈小琳[1] 李竞[1] 文重远[1] 孙永林[1] 王颖[1] 蔡小俐[1] 周波[1] 李珍瑾[1] 

机构地区：[1]武汉大学人民医院内分泌科,430060

出　　处：《中华内分泌代谢杂志》2008年第5期521-522,共2页Chinese Journal of Endocrinology and Metabolism

基　　金：湖北省卫生厅科研基金资助项目（基金编号：NX200517）

摘　　要：观察肥胖和非肥胖葡萄糖耐量正常的2型糖尿病一级亲属胰岛素敏感性、B细胞功能和血清超敏C反应蛋白（hs-CRP）水平，结果显示肥胖2型糖尿病一级亲属存在胰岛素抵抗、B细胞功能受损和hs-CRP水平升高，且胰岛素抵抗、hs-CRP与腰围正相关。Insulin sensitivity, G-cell function and serum high-sensitivity C-reactive protein （hs-CRP） levels were observed in obese and non-obese normoglycemic first-degree relatives of type 2 diabetic patients （FDR）. The results showed that there existed insulin resistance, G-cell dysfunction and increased serum hs-CRP level in obese FDR of type 2 diabetic patients. Moreover, insulin resistance and increased CRP level were positively related to waist circumference.

关 键 词：肥胖症 糖尿病 2型 一级亲属 胰岛素抵抗 C反应蛋白质 

分 类 号：R587.1[医药卫生—内分泌] R589.2[医药卫生—内科学]