不同糖耐量个体空腹血浆Preptin水平变化及其相关因素  

Fasting plasma preptin levels and relevant factors in the subjects with different glucose tolerances

作　　者：唐毅[1] 杨刚毅[1] 李伶[2] 李钶[1] 陈文雯[1] 

机构地区：[1]重庆医科大学附属第二医院内分泌科,400010 [2]重庆医科大学附属第二医院检验系临床生化教研室,400010

出　　处：《中华内分泌代谢杂志》2008年第5期527-528,共2页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金资助项目（30771037）;国家教委春晖计划资助项目（2003-56）;重庆市教委科研基金（JK050304）

摘　　要：采用放射免疫法测定不同糖耐量个体空腹血浆Preptin水平。结果显示空腹血浆Preptin水平女性高于男性，并且2型糖尿病患者血浆Preptin水平明显高于糖耐量受损者和正常对照者。空腹血浆Preptin水平与舒张压、甘油三酯、总胆固醇、高密度脂蛋白胆固醇、游离脂肪酸、糖负荷后2h血糖、HbA1c和HOMA-IR呈明显正相关。提示血浆Preptin水平可能与糖脂代谢和胰岛素抵抗有关。Fasting plasma preptin level was assayed by RIA in the patients with different glucose tolerances. Regarding fasting plasma preptin levels, it was higher in females than in males. Fasting plasma preptin level was increased in patients with type 2 diabetes as compared with subjects of impaired glucose tolerance and normal controls, and there were positive correlations with diastolic blood pressure, blood triglyceride, total cholesterol, high-density lipoprotein-cholesterol, free fatty acids, 2 h plasma glucose after glucose load, HbA1c and HOMA-IR, suggesting a potential link between preptin and glucose-lipid metabolism and insulin resistance.

关 键 词：PREPTIN 糖尿病 2型 胰岛素抵抗 

分 类 号：R587.1[医药卫生—内分泌] R512.6[医药卫生—内科学]