露蜂房蛋白对红白血病小鼠脾和骨髓的超微结构的影响  

Effect of Protein from Nidus Vespae on the Ultrastructure of Spleen and Bone Marrow of Leukemia Mouse

作　　者：张雪莉[1] 张圣明[1] 王强[2] 吴洪娟[1] 李锋杰[1] 

机构地区：[1]潍坊医学院组织胚胎学教研室,山东潍坊261042 [2]寿光市人民医院

出　　处：《潍坊医学院学报》2008年第4期345-346,I0002,共3页Acta Academiae Medicinae Weifang

基　　金：山东省中医药管理局资助项目(课题编号:2003127)

摘　　要：目的观察露蜂房蛋白对红白血病小鼠的脾和骨髓的影响。方法用EL9611细胞株制备红白血病小鼠模型,常规制备超薄切片,透射电镜下观察红白血病小鼠脾和骨髓的超微结构。结果红白血病小鼠脾和骨髓红白血病细胞染色质边集,滑面内质网扩张,线粒体呈现空泡样改变,有的出现凋亡小体。结论露蜂房蛋白在体内具有明显的诱导红白血病细胞凋亡的作用,并且白血病细胞呈现典型细胞凋亡的超微结构改变。Objective To observe the effect of protein from Nidus Vespae on the uhrastructure of spleen and bone marrow of leukemia mouse. Methods Prepared the mouse model using EL9611 cells line, and obtain the spleen and bone marrow of variouse group respectively, observed the ultrastructure of the spleen and bone marrow under the TEM. Results Under TEM, the chromatin of spleen and bone marrow leukemia cells condensed, smooth endoplasmic reticulum widen, mitochondrium vacuolused and there are apoptosis body. Conclusion NVP has the effect of inducing the leukemia cells apoptosis obviousely,and it＇s the typical change of apoptosis.

关 键 词：露蜂房 蛋白 红白血病 超微结构 EL9611 

分 类 号：R322.2[医药卫生—人体解剖和组织胚胎学]