化瘀解毒汤治疗缺血性脑血管病急性期多时相临床症状的评价  

Assessment of Huayu Jiedu Tang on Multi-Phase Clinical Symptoms of Ischemic Cerebral Vascular Disease in Acute Stage

作　　者：钟利群[1] 孙塑伦[1] 贾建平[2] 高利[2] 王硕仁[1] 高颖[1] 邹忆怀[1] 李宁[2] 徐娟[2] 

机构地区：[1]北京中医药大学东直门医院,北京100700 [2]首都医科大学宣武医院,北京10005

出　　处：《世界中西医结合杂志》2008年第7期393-396,共4页World Journal of Integrated Traditional and Western Medicine

摘　　要：目的:观察比较中西医量表评价缺血性脑血管病急性期的临床症状和疗效差异。方法:将51例缺血性脑血管病患者随机分成治疗组25例和对照组26例,急性期的14 d分成4段,对照组常规治疗,治疗组在常规治疗的基础上加用组方化瘀解毒汤治疗,用《美国国立卫生研究院卒中量表》(NIHSS)、《脑卒中患者临床神经功能缺损程度评分标准(改良爱丁堡+斯堪迪纳维亚研究组制定)》(SCAND)和《中风病证候诊断标准》三个量表分别评价各段的临床症状及疗效,分析各量表的特点。结果:各治疗组和对照组的量表评分随治疗时间的变化都呈现共同的发展态势,其中中医中风证候量表和NIHSS表现相同的趋势,治疗组11￣14 d的NIHSS分值与治疗组和对照组的0￣72 hNIHSS分值不同;治疗组11￣14 d的中风证候量表分值与0￣7 d的得分不同;对照组11￣14 d中风证候量表分值与对照组0￣72 h不同,得到统计学的验证。从总体水平来说,中医证候分值有极显著性差异(P<0.01),治疗干预有效。结论:与SCAND比较,NIHSS更能全面反映脑血管病患者的症状变化。中医中风证候量表与NIHSS类似,可以作为评价缺血性脑血管病急性期临床症状和疗效的工具,化瘀解毒汤具有较好的临床疗效。Objective：To observe and compare between Chinese and western scales the assessment differences, clinical symptoms and therapeutic effect in the acute stage of ischemic cerebral vascular disease. Methods：51 cases of isehemic cerebral vascular disease were randomized into treatment and control groups. 4 phases, were divided among 14d of acute stage. In control group,the routine therapy was administrated and in treatment group, beside the routine therapy, Huayu Jiedu Tang was supplemented. Three different scales were adopted to assess the clinical symptoms and therapeutic effect at each phase,namely National Institutes of Health Stroke Scale （NIHSS）, Modified Edinburgh-Scandinavian Stoke Scale （SCAND）and Diagnostic Criteria of Stroke Syndrome in Chinese medicine;additionally,the analysis was underway on the characteristics of each scale. Results：The scale assessments presented common development tendency with the changes in treatment time in either treatment group or control group. Of which, Stroke Syndrome Scale of Chinese medicine（SSS）and NIHSS manifested the same tendency. NIHSS values in 11-14d of treatment group were different from those in 0-72h in treatment group and control group. SSS values in 11-14d of treatment group were different from those in 0-7d. SSS values in 11-14d of control group were different from those in 0-72h of control group,which had been validated in statistics. Generally,SSS values presented extremely significant differences （P〈0.01）,indicating the effective intervention. Conclusion：Comparing with SCAND, NIHSS can much completely reflect the symptomatic changes in cerebral vascular disease. Similar to NIHSS, SSS of Chinese medicine can be the means for the assessment of clinical symptoms and therapeutic effect of ischemic cerebral vascular disease in acute stage. Additionally, Huayu Jiedu Tang achieves quite good clinical therapeutic effect.

关 键 词：急性缺血性脑血管病 多时相 疗效评价 化瘀解毒汤 

分 类 号：R285.6[医药卫生—中药学]