玄丹巴布剂对家兔乳腺增生模型作用的实验研究  被引量:4

Experimental study of Xuandan cataplasm on rabbit models of mammary gland hyperplasia

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作  者:孟舒 姜泓[2] 关艳敏 卢明文 杨立群 

机构地区:[1]辽宁省计划生育研究院,辽宁沈阳110031 [2]中国医科大学,辽宁沈阳110001

出  处:《中国医院药学杂志》2008年第20期1738-1740,共3页Chinese Journal of Hospital Pharmacy

基  金:辽宁省科技厅科技攻关(项目编号:2004225003)

摘  要:目的:观察玄丹巴布剂抑制和治疗乳腺增生病的效果。方法:选用健康♂大耳白兔65只,随机分成6组,用苯甲酸雌二醇注射液复制乳腺增生病模型。在造模成功后,分别使用玄丹巴布剂外贴乳房部位和乳癖消片灌胃给药,对照观察乳房外观形态、组织学形态和血浆中雌二醇的含量。结果:玄丹巴布剂能抑制家兔乳腺增生,降低血浆中雌二醇含量。结论:玄丹巴布剂对苯甲酸雌二醇注射液所致的乳腺增生病有一定的治疗作用,可部分地使其恢复正常或减轻其增生程度。OBJECTIVE To observe the effect of Xuandan cataplasm on inhibiting and treating mammary gland hyperplasia disease. METHODS 65 healthy female big-ear rabbits were selected and randomly divided into six groups. The rabbit models of mammary gland hyperplasia were made with estradiol benzoate. After the course of making model, Xuandan cataplasm and Rupixiao tablets were used on the breast. The outward appearance and histological structure of the breast and the content of dihydrotheelin in plasma were compared and observed. RESULTS Xuandan cataplasm could inhibit mammary gland hyperplasia of rabbit models and decrease the content of dihydrotheelin in plasma. CONCLUSION Xuandan eataplasm has definit therapeutic effect on mammary gland hyperplasia disease induced by estradiol benzoate and can partially get right or lighten hyperplasia degree.

关 键 词:乳腺增生 玄丹巴布剂 家兔 

分 类 号:R285.5[医药卫生—中药学]

 

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