海因法合成DL-苯丙氨酸  

Synthesis of DL-Phenylalanine With Hydantoin Method

作　　者：刘莉 刘毅[2] 张玲[2] 李健[2] 

机构地区：[1]徐州环境保护研究所,江苏徐州221008 [2]徐州医学院药学系,江苏徐州221004

出　　处：《云南化工》2008年第5期15-19,共5页Yunnan Chemical Technology

基　　金：徐州医学院院长专项人才基金(批准号:07KJZ07)资助项目

摘　　要：对DL-苯丙氨酸合成方法进行改进。以水为溶剂,乙醇胺为催化剂,将苯甲醛与海因经Knoevenagel缩合反应制得亚苄基海因,收率为90.1%;m(亚苄基海因)∶m(反应体系总质量)=10∶1,在V(3 mol/LNaOH水溶液)∶V(甲醇)=1∶1,反应温度25℃下,以m(亚苄基海因)∶m(雷尼镍)=10∶1为催化剂,氢气压力200 kPa,反应20 h,获得苄基海因,收率为90.6%;经碱水解后得到DL-苯丙氨酸,收率为85.0%;三步反应总收率为69.4%。雷尼镍催化剂回收后,重复使用3次,反应收率无明显下降。DL - phenylalanine was synthesized, and 5 - benzylidene hydantion was prepared with the yield of 90. 1% by the Knoevenagel condensation of benzaldehyde and hydantoin, with water as solvent and ethanolamine as catalyst. 5 - benzylidenehydantion was hydrogenated to produce 5 - benzylhydantoin with yield 90.6% at hydrogen pressure of 200 kPa with Raney nickel as catalyst in alkaline media. The benzylhydantoin was hydrolyzed by alkaline hydrolysis to afford DL - phenylalanine with yield of 85.0%. The total yield of the three - step reaction was 69.4%, and the catalysts could be easily recovered and reused four times without notable decrease of the catalytic activity.

关 键 词：DL-苯丙氨酸 雷尼镍 苄基海因 催化加氢 

分 类 号：TQ463.4[化学工程—制药化工] R979.1[医药卫生—药品]