溶瘤单纯疱疹病毒治疗技术及其进展  

Oncolytic herpes simplex virus and its advances in cancer therapy

作　　者：田聆[1] 薛京伦[1] 贾韦国[1] 

机构地区：[1]复旦大学生命科学学院遗传学研究所暨遗传工程国家重点实验室,上海200433

出　　处：《生命科学》2008年第5期734-741,共8页Chinese Bulletin of Life Sciences

基　　金："863"计划重点项目(2007AA021010)

摘　　要：溶瘤病毒治疗是当前肿瘤治疗技术的研究热点,溶瘤单纯疱疹病毒是目前研究最多的,也是抗肿瘤作用最好的溶瘤病毒之一,本文就主要介绍溶瘤单纯疱疹病毒的优势、遗传操作、发展策略、研究进展及靶向性策略等。Oncolytic virotherapy represents an emerging modality with tremendous promise for cancer treatment. Among various oncolytic virues, oncolytic herpes simplex virus is one of the most widely explored agents and shows significant anti tumor activity. In this review, we mainly discuss the advantages of oncolytic HSV, the principles of HSV genetic manipulation, the strategies of oncolytic HSV development and targeting, the advances and challenges of oncolytic HSV in cancer therapy.

关 键 词：溶瘤病毒 病毒治疗 基因治疗 

分 类 号：R373[医药卫生—病原生物学] R730.59[医药卫生—基础医学]