金叶子中抑制膜结合型PGE_2合酶-1表达活性物质的分离与鉴定(英文)  

Isolation and Identification of mPGES-1 Expression Inhibitor from Craibiodendron yunnanense

作　　者：郭雷[1] 龚邦强[2] 

机构地区：[1]淮海工学院海洋学院,连云港222005 [2]华东理工大学生物工程学院,上海200237

出　　处：《天然产物研究与开发》2008年第5期839-841,共3页Natural Product Research and Development

基　　金：Natural Sciences Fund of Huaihai Institute of Technology

摘　　要：在从天然产物筛选抗炎物质的过程中,应用有机溶媒萃取、浓缩及层析分离纯化后,从金叶子中得到三个化合物:槲皮素(1)、番石榴苷(2)、栎素(3)。化合物2为首次从此植物中分离鉴定,化合物1显示了强烈的抑制mPGES-1基因表达的活性,其IC50值为35.40μg/mL。In the course of searching for anti-inflammatory agents from natural products, three known compounds were i- solated from the ethanol extract of the leaves of Craibiodendron yunnanense W. W. Smith and identified as quercetin （ 1 ）, quercetin 3-O-α-L-arabinopyranoside （ guaijaverin ,2 ）, quercetin 3-O-α-L-rhamnopyranoside （ quercitrin ,3 ）. Compound 2 was isolated for the first time from this plant. Among these compounds, compound 1 showed significant bioactivity against mPGES-1 expression with ICso value of 35.40 μg/mL.

关 键 词：金叶子 膜结合型PGE2 合酶-1 类风湿性关节炎 槲皮素 番石榴苷 栎素 

分 类 号：R284.2[医药卫生—中药学] Q946.91[医药卫生—中医学]