异丙基硫杂蒽酮(ITX)的大鼠致癌性实验研究  

Study on the carcinogenicity of ITX in the rats

作　　者：王静[1] 王晓军[1] 杨友润[1] 姜文玲[1] 谢永玲[1] 张力[1] 张晶[1] 刘英华[1] 李新[1] 

机构地区：[1]天津市疾病预防控制中心,天津300011

出　　处：《毒理学杂志》2008年第5期352-355,共4页Journal of Toxicology

摘　　要：目的研究异丙基硫杂蒽酮(ITX)原药对大鼠的致癌性。方法分别用含ITX原药1000,250,62.5 mg/kg的饲料给大鼠连续喂饲染毒2年。观察动物的一般表现,记录其体重和进食量,观察实验动物的肿瘤发生情况,包括:发生肿瘤的种类、数量、出现肿瘤的时间等。结果实验期间各组动物体重均呈现增长相,以发育高峰期(前3个月)增长速度最快,以后渐缓,12个月后趋于平稳。雄性高剂量组动物体重略低于对照组,其他各组动物体重变化差异无统计学意义。总进食量两性别动物与对照组比较差异未见统计学意义,但总食物利用率雄高剂量组明显低于对照组(P<0.05)。大体解剖及组织学检查显示各剂量组动物肿瘤发生率未高于对照组。结论实验剂量下未见ITX引起大鼠肿瘤发生率增高。Objective To research the carcinogenieity of ITX in the rats. Methods Four groups of rats were fed with foodstuff containing ITX in the doses of 1000,250,62.5 mg/kg respectively for 2 years. Behavior, weight gain and food intake as well as tumorigenesis including categories, quantities, occurrence etc were recorded. Results The body weight of rats in each group was increased in the crest-time of development （ the first 3 months of the experiment period）, slowing down afterwards and reaching the equability after 12 months. The weight gain in each group of treatment was not significantly different except that that of the high dosage male group was lower than that of the control. No statistical difference was observed in the total food intake of different groups of both genders compared with the control group. However, the total food availability in high dosage male group was significantly lower than its control （P 〈 0.05）. The tumorigenesis by necropsy, histological examination in each treated group was not higher than that in the control. Conclusion It was shown that the tumorigenesis was not elevated in rats by ITX at the dosage under investigation.

关 键 词：异丙基硫杂蒽酮(ITX) 大鼠 致癌性 

分 类 号：R994.3[医药卫生—毒理学]