磁共振灌注成像对肝纤维化的实验性研究  

Experimental Study of MR Perfusion Imaging in Liver Cirrhosis

作　　者：胡晓峰[1] 刘斌[2] 钱银锋[2] 张家文[2] 刘可夫[3] 余永强[2] 

机构地区：[1]安徽省立医院放射科,合肥230001 [2]安徽医科大学第一附属医院放射科,合肥230022 [3]苏州市立医院北区,215008

出　　处：《放射学实践》2008年第10期1071-1075,共5页Radiologic Practice

摘　　要：目的:评价磁共振灌注成像在肝纤维化中的作用。方法:选取普通级36只家兔,随机分为一组对照组和三组实验组。对实验组家兔注射四氯化碳溶液,建立家兔肝纤维化模型,然后分组行磁共振灌注成像。磁共振灌注成像采用SE-EPI序列,通过软件处理后采集肝实质和门静脉的信号强度,计算出相对肝门静脉局部血流容积、相对肝门静脉局部血流量、平均通过时间、最大信号下降百分比和相对肝血流容积,每次试验结束后取肝脏行病理检查。对MR灌注参数与病理改变作统计学分析,统计学处理采用SPSS11.0统计软件包。结果:MR灌注成像参数中最大信号下降百分比在各组间分别为0.750±0.080、0.534±0.168、0.572±0.119及0.626±0.030。经统计学处理差异有显著性意义(P<0.05)。其他参数在各组之间有相对减少或增加的趋势,但无统计学意义。结论:MR灌注成像参数中仅最大信号下降百分比有统计学意义,但其对肝纤维化分期的价值尚需进一步的研究。Objective：To evaluate the role of MR perfusion imaging in the diagnosis of hepatic fibrosis. Methods：36 rabbits were divided into three experimental groups and one control group randomly. Carbon tetrachloride was injected intraperitoneally to make the model of rabbit liver fibrosis in three experimental groups. MR perfusion imaging was performed for the control group and experimental groups. The changes of hepatic pathology were observed after each experiment. MR perfusion data of different stages were compared with pathologic analysis with SPSS 11.0 statistical software. One-way analysis of variance was used to compare every rank data respectively. P〈0. 05 was considered statistically significant. Results：Maximum signal reduction ratios were 0. 750±0. 080,0. 534±0. 168,0. 572±0. 119,0. 626±0. 030 in the control group and experimental groups respectively, which showed significant difference. Other parameters were not statistically different, there were only trend of increase or decrease. Conclusion：The stages of hepatic fibrosis could be evaluated by maxi mum signal reduction ratios from MR perfusion data objectively,which needs further study.

关 键 词：模型 动物 肝硬化 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R575.2[医药卫生—诊断学]