获得性免疫缺陷综合征性视乳头病变  

Study on pathological changes of AIDS optic papilla

作　　者：阳桥生[1] 荣德彦[1] 唐柳松[1] 

机构地区：[1]中国广西壮族自治区柳州市眼科医院,545001

出　　处：《国际眼科杂志》2008年第10期2049-2051,共3页International Eye Science

摘　　要：目的:探讨获得性免疫缺陷综合征(acqured immunodeficiency syndrome,AIDS,简称艾滋病)发生视乳头病变的类型及其与CD4+T淋巴细胞的关系。方法:回顾分析107例(214眼)艾滋病患者经眼底彩照及眼底荧光血管造影(fluorescein angiography,FFA)检查确诊的视乳头病变患者,统计AIDS性视乳头病变的发生率及病变类型以及与CD4+T淋巴细胞数之间的关系。结果:107例(214眼)AIDS患者发生视乳头病变71眼,占33.2%;其中,前段缺血性视神经病变30眼,占42.2%(30/71);视盘水肿12眼,占16.9%(12/71);无体征性视神经病变29眼,占40.8%(29/71)。CD4+T淋巴细胞≤50个/μL发生视乳头病变59眼,未发生视乳头病变75眼,发病率44.0%(59/134);CD4+T淋巴细胞≥51个/μL发生视乳头病变12眼,未发生视乳头病变68眼,发病率15.0%(12/80)。经双侧检测统计:χ2=19.042,P=0.000。说明组间具有显著差异性。结论:AIDS视乳头病变的类型呈多样性,且CD4+T淋巴细胞数越少,发生视乳头病变的几率越大。AIM： To analyze the types of AIDS optic papilla and its relationship with CD4^＋ T lymph cell. METHODS： A total of 107 cases （214 eyes） of AIDS patients were retrospectively analyzed, who had been checked through the color fundus copy and fluorescein angiography （FFA） and diagnosed as optic papilla. The rate and the relationship between the types of AIDS optic papilla and the numbers of CD4^＋ T lymph cell were counted up. RESULTS; Of all cases, 44 cases （71 eyes） got optic papilla, covering 41.12 % （33.2%）, among which 30 eyes （42.2%） were of front iron-deficiency optic changes, 12 eyes （16.9%） of optic discus dropsy, and 29 eyes （40.8%） of no sign. Of 67 cases 134 eyes with CD4^＋ T lymph cell ≤50/uL, 37 cases 59 eyes （55.2%） got optic papilla. Of 40 cases 80 eyes with CD4^＋ T lymph cell ≥51 /uL, 7 cases 12 eyes （17. 5%） got optic papilla. By checking double sides, the results showed that there were obvious differences between tow groups （X^2 = 14.722, P = 0.000）. CONCLUSION. The types of AIDS optic papilla are varied. And the less the numbers of CD4^＋ T lymph cell are. the more possible the optic papilla will be.

关 键 词：获得性免疫缺陷综合征 视乳头病变 淋巴细胞 

分 类 号：R512.91[医药卫生—内科学] R774.605[医药卫生—临床医学]