Democratic organization of the thalamocortical neural ensembles in nociceptive signal processing  

作　　者：LUO Fei WANG Jin-Yan 

机构地区：[1]Key Laboratary of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China

出　　处：《生理学报》2008年第5期669-676,共8页Acta Physiologica Sinica

基　　金：the National Natural Science Foundation of China(No.30570577,30770688,30700223);the 100 Talents Programme of Chinese Academy of Sciences,the National Hi-Tech Development Program of China(No.2006AA02Z431);a grant from Beijing Natural Science Foundation(No.5082008)to FL;a Young Scientist grant(No.07CX051005)from ChineseAcademy of Science to JYW

摘　　要：Acute pain is a warning protective sensation for any impending harm.However,chronic pain syndromes are often resistant diseases that may consume large amount of health care costs.It has been suggested by recent studies that pain perception may be formed in central neural networks via large-scale coding processes,which involves sensory,affective,and cognitive dimensions.Many central areas are involved in these processes,including structures from the spinal cord,the brain stem,the limbic system,to the cortices.Thus,chronic painful diseases may be the result of some abnormal coding within this network.A thorough investigation of coding mechanism of pain within the central neuromatrix will bring us great insight into the mechanisms responsible for the development of chronic pain,hence leading to novel therapeutic interventions for pain management.Acute pain is a warning protective sensation for any impending harm. However, chronic pain syndromes are often resistant diseases that may consume large amount of health care costs. It has been suggested by recent studies that pain perception may be formed in central neural networks via large-scale coding processes, which involves sensory, affective, and cognitive dimensions. Many central areas are involved in these processes, including structures from the spinal cord, the brain stem, the limbic system, to the cortices. Thus, chronic painful diseases may be the result of some abnormal coding within this network. A thorough investigation of coding mechanism of pain within the central neuromatrix will bring us great insight into the mechanisms responsible for the development of chronic pain, hence leading to novel therapeutic interventions for pain management.

关 键 词：神经系统 疼痛 处理方法 临床分析 

分 类 号：Q42[生物学—神经生物学] Q426[生物学—生理学]