Mage-D1的结构与生物学功能  

Structure and biological functions of Mage-D1

作　　者：丁劼[1] 刘少君[1] 

机构地区：[1]军事医学科学院基础医学研究所,北京100850

出　　处：《军事医学科学院院刊》2008年第5期482-485,共4页Bulletin of the Academy of Military Medical Sciences

基　　金：国家自然科学基金资助项目(30430310)

摘　　要：Mage-D1是黑素瘤相关抗原MAGE家族Ⅱ类的一个成员,不仅具有该家族所共有的MAGE保守序列MHD结构域,其N端还包含MHD2结构域和WQXPXX多肽重复结构域。与MAGEⅠ类成员不同的是,Mage-D1的功能并不限于胚胎发育、生殖细胞发育和肿瘤发生上。近年研究表明,Mage-D1是p75NTR,UNC5H1,XIAP,Dlx/Msx,Ror2等分子的相互作用蛋白,它在细胞存活、凋亡以及细胞周期和分化中发挥重要调节功能。更为重要的是,MAGE家族Ⅱ类另一个主要成员源自神经分化EC细胞蛋白necdin促进神经元和肌细胞分化的功能,是通过Mage-D1调节Dlx/Msx家族成员的转录活性实现的。本文主要就近年关于Mage-D1结构和生物学功能的研究进行综述和分析。Mage-D1, A member of type Ⅱ melanoma-associated antigens （ MAGE ） genes, possesses an N-terminal MHD2 domain and a central WQXPXX repeat domain in additional to the C-terminal MHD domain which is a unique highly conserved domain shared by all MAGE family members. Different from type I MAGE genes, who may play crucial roles in embryogenesis, germ cell genesis and tumorigenesis, Mage-D1, identified as a binding partner of the p75NTR, UNC5 H1, XIAP, Dlx/Msx homeodomain proteins, Ror2 and so forth, shows important functions in cell survival, apoptosis, cell cycle progression and differentiation. Intriguingly, necdin, another member of type Ⅱ MAGE genes, associates with Dlx/Msx homeodomain proteins via Mage-D1 to promote neuronal and myogenic differentiation. This review summarizes recent findings concerning the structure and biological functions of Mage-D1, which may provide clues to future studies on other type Ⅱ MAGE members.

关 键 词：Mage—D1 MAGE家族Ⅱ类 NECDIN 细胞凋亡 细胞周期 细胞分化 

分 类 号：Q51[生物学—生物化学]