在玻碳电极上用微分脉冲溶出伏安法检测盐酸甲氧氯普胺  

Determination of Metoclopramide Dihydrochlorid by Differential Pulse Stripping Voltammetry

作　　者：倪永年[1,2] 王林[1] 

机构地区：[1]南昌大学化学系,江西南昌330031 [2]南昌大学食品科学与技术国家重点实验室,江西南昌330047

出　　处：《南昌大学学报（理科版）》2008年第4期367-369,373,共4页Journal of Nanchang University(Natural Science)

基　　金：国家自然科学基金资助项目(20562009);江西省自然科学基金资助项目(0620041);中科院长春应化所电分析化学重点实验室项目(SKLEAC2004-3);长江学者及创新团队项目(IRT0540)

摘　　要：在pH3．29的Britton—Robinson缓冲溶液中，盐酸甲氧氯普胺在E=1150mV（vs．Ag／AgCl）处具有良好电化学氧化峰，本实验采用循环伏安法和线性扫描溶出伏安法等对该体系进行研究，发现采用线性扫描溶出伏安法时能得到较大的灵敏度，电极反应呈不可逆现象，并具有一定的吸附性，在30s时能达到吸附平衡。该体系的伏安波谱峰电流与浓度成正比，线性范围为1．2～25μg/mL，检出限为0．44μg／mL。利用该方法对针剂样品中的盐酸甲氧氯普胺进行直接测定，获得了较好的定量分析结果。A differential pulse stripping vohammetric method for the determination of Metoclopramide Dihydrochloride in pharmacy was developed. The electrochemical behavior and vohammetric parameters of Metoclopramide Dihydrochloride at a glass carbon electrode were investigated. In the Britton - Robinson （ B - R） buffer, Metoclopramide Dihydrochloride has an irreversible oxidative peak at the potential of 1150 mV and the peak current was linear with its concentration in the range of 1.2 - 25.0μg/mL with detection limit of 0. 4428μg/mL. The proposed method is simple,easy to operation and hard to be interfered. It was applied to the determination of Metoclopramide Dihydrochloride in several drug samples with satisfactory results.

关 键 词：盐酸甲氧氯普胺 线性扫描溶出伏安法 电化学 

分 类 号：O657.1[理学—分析化学]