氢氧化镁对利培酮微球释放速率的调控  

Modulation of Release Rates of Risperidone Loaded Microspheres by Mg(OH)_2

作　　者：胡振华[1] 袁伟恩[2] 吴飞[2] 王柏[1] 金拓[2] 

机构地区：[1]中国药科大学药学院,南京210009 [2]上海交通大学药学院,200240

出　　处：《医药导报》2008年第11期1374-1376,共3页Herald of Medicine

摘　　要：目的用氢氧化镁调节利培酮PLGA微球的释放速度。方法采用S/O/W液中干燥法制备包裹氢氧化镁的利培酮PLGA微球,用高效液相色谱法测定微球载药量,并考察其体外释放等性质。结果制得的微球粒径约50μm,呈较好的球形。氢氧化镁加快了PLGA微球对利培酮的释放,释放32 d后,载有氢氧化镁的微球累积释药量均超过90%,而对照组不到70%。不同含量氢氧化镁对PLGA微球释药速度的影响也不同。结论可以通过改变加入氢氧化镁的量来改善PLGA微球释放利培酮的行为,达到理想治疗效果。Objective This paper focused on adjusting the release rates of risperidone from PLGA microspheres by coencapsulating Mg （OH）2. Methods Risperidone loaded microspheres co-encapsulated Mg （OH）2 were prepared by solid-inoil-in-water（S/O/W） emulsion solvent evaporation method. HPLC was used to determine risperidone loading capacity and evaluate the in-vitro release of microspheres. Results The particles, about 50 um, possessed well spherical shape. Mg （OH）2 accelerated the release rates of risperidone from PLGA microspheres. After 34 days, the percentage of released risperidone from microspheres with Mg （ OH ） 2 was all more than 90%, but the control was not up to 70%. The in vitro release profiles of microspheres were various with different concentrations of Mg （OH）2 co-encapsulated. Conclusion The amount of Mg （OH） added into microspheres can improve the release behavior of risperidone from PLGA microspheres to achieve more perfect clinical effect.

关 键 词：利培酮 氢氧化镁 PLGA微球 

分 类 号：TQ450.1[化学工程—农药化工]