氨溴索雾化液的稳定性考察  

Study on the Stability of Ambroxol Nebulisation

作　　者：赵环宇[1] 王昕[1] 王靓[1] 

机构地区：[1]首都医科大学附属北京同仁医院药剂科,100730

出　　处：《医药导报》2008年第11期1384-1385,共2页Herald of Medicine

摘　　要：目的考察氨溴索雾化液中主要成分的配伍稳定性。方法按处方配制氨溴索雾化液，冰箱2～8℃冷藏保存，于0，1，2，3，4d观察雾化液外观，并采用反相高效液相色谱法测定盐酸氨溴索及地塞米松磷酸钠的含量。结果氨溴索雾化液在5d内外观无变化，主要成分含量均保持在初始浓度的96％以上。结论雾化液在2～8℃保存条件下，5d内性质稳定。Objective To evaluate the compatible stability of main contents in the ambroxol nebulisation. Methods Ambroxol nebulisation was prepared according to the prescription and stored at 2 - 8 ℃. The appearance of the solution was observed at 0,1,2,3,4 d. Ambroxol Hydrochloride and dexamethasone sodium phosphate were determined by RP-HPLC. Results No obvious change was noted in appearance within 5 days. The main contents consistently remained over 96%. Conclusion Nebulisation could be stable at 2 -8 ℃ and used within 5 days.

关 键 词：雾化液 稳定性 氨溴索 盐酸 地塞米松磷酸钠 

分 类 号：R971.7[医药卫生—药品] R927.1[医药卫生—药学]