RANKL/RANK/OPG系统造成人工关节假体无菌性松动的机制  

The RANKL/RANK/OPG System and Aseptic Loosening of Artificial Joint

作　　者：陈昱铭[1,2] 熊奡[2] 曾晖[2] 

机构地区：[1]汕头大学医学院,广东汕头515041 [2]北京大学深圳医院骨关节科,广东深圳518036

出　　处：《医学综述》2008年第21期3205-3208,共4页Medical Recapitulate

基　　金：深圳市科技计划项目(200702042);教育部留学回国人员科研启动基金(2006-331号)

摘　　要：人工关节假体无菌性松动是影响关节置换术长期疗效的重要因素。许多研究表明,无菌性松动与RANKL/RANK/OPG系统的关系密切。该系统是在破骨细胞分化、激活和凋亡过程中的一个重要信号调节系统,将骨代谢、免疫系统和内分泌系统紧密地联系起来。研究发现,体内多种激素和细胞因子等均直接或间接地调节该系统的表达,调控RANKL、OPG二者之间的平衡,从而介导破骨细胞的分化和功能而达到影响骨代谢的作用。该文就近年RANKL/RANK/OPG系统与人工关节无菌性松动机制的研究进展作一综述。Aseptic loosening of artificial joint is the important factor affecting the in-service life of prosthetic replacement. Many researches indicate there is a close correlation between the RANKL/RANK/OPG system and aseptic loosening. This system regulates osteoclast formation, activation and survival, it makes bone metabolism, immune system and endocrine system connect tightly. Researches discover many hormones and cytokines can regulate the expression of this system directly or indirectly, to mediate the differentiation and function of osteoclast, and finally to influence bone metabolism. This article reviews studies about the role of the RANKL/RANK/OPG system in aseptic loosening.

关 键 词：细胞核因子κB受体活化因子配基 细胞核因子κB受体活化因子 骨保护素 人工关节 无菌性松动 

分 类 号：R687.42[医药卫生—骨科学]