胰腺-十二指肠同源盒1与胰岛β细胞受体相互作用的研究进展  

Research Progress on the Interaction between Pancreatic-Duodenal Homeobox-1 and Receptors of Islet β-Cell

作　　者：侯毅翰[1] 杨立勇[1] 

机构地区：[1]福建医科大学附属第一医院内分泌科,福州350005

出　　处：《医学综述》2008年第21期3211-3214,共4页Medical Recapitulate

基　　金：福建省教育厅科研基金(JB06240);福建医科大学教授学术发展基金(JS06034)

摘　　要：胰腺-十二指肠同源盒1(PDX-1)作为调节激素表达的转录因子特异表达于胰岛内分泌细胞。它含有3个结构域,即氨基末端转录活化结构域、同源结构域、羧基末端结构域,并且不同物种间PDX-1的氨基酸序列保持高度的同源性。活化的PDX-1与核输入受体importinβ1结合形成复合物从细胞质转位到细胞核内发挥生物学功能。多种细胞受体与配体结合后通过不同的信号转导通路参与PDX-1的表达和生物学活性的调控。胰高血糖素样肽1受体、过氧化物酶体增殖物激活受体、Fas、肝X受体的活化将促进PDX-1的表达与转位,而微小异源二聚体伙伴基因、糖皮质激素受体的活化对PDX-1功能的发挥则有抑制作用。As a transcription factor regulating the expression of hormones, pancreatic-duodenal homeobox-1 （ PDX-1 ） specially expresses in endocrine ceils of pancreas islet. PDX-1 contains 3 domains including N-terminal transactivation domain, homeodomain and C-terminal domain, and its amino acid sequence keeps highly conserved among different species. The activated PDX-1 interacts with nucleus import receptor importin β1 and forms a complex. The complex can translocate from cytoplasm to cell nucleus, where PDX-1 could display its biological functions. After binding to their ligands respectively, several cell receptors involve in expression of PDX-1 and regulation of its biological activity via different signal transductions. The activation of glucagon-like peptide-1 receptor, perosisome proliferator activated receptors, Fas and liver X receptors would promote the expression and translocation of PDX-1 ,but the activation of SHP and glucocorticoid receptor may suppress the function of PDX-1.

关 键 词：胰腺-十二指肠同源盒1 受体 糖尿病 

分 类 号：R587.1[医药卫生—内分泌]