蚌埠市出生缺陷受母亲因素影响的调查分析  

Investigation and Analysis on Maternal Influencing Factors of Birth Defects in Bengbu City

作　　者：陈雪芹[1] 芈静[2] 周纯先[2] 孟灿[3] 张睿[1] 王云[1] 王峙峰[1] 陈兰举[4] 

机构地区：[1]安徽省蚌埠市计划生育服务站,233000 [2]蚌埠医学院预防医学系 [3]上海复旦大学公共卫生学院,200433 [4]蚌埠医学院第一附属医院儿科,233004

出　　处：《中华全科医学》2008年第11期1179-1180,共2页Chinese Journal of General Practice

基　　金：安徽省人口和计划生育委员会(05-02);安徽省教育厅自然科学基金(KJ2007B334ZC)

摘　　要：目的了解蚌埠地区0～5儿童出生缺陷患病率,探索蚌埠地区出生缺陷的危险因素。方法应用分层按比例整群抽样的方法。对样本点的0～5岁儿童进行筛查。筛查出的出生缺陷具有明确诊断或者经医师体检诊断出生缺陷儿作为调查对象。对母亲的年龄、文化、患病、用药、接触毒物、吸烟等情况进行统计分析,提出可能的危险因素。结果共筛查0～5岁儿童16 698人,检出BD病例883例,BD发生率为5.29%。对比不同年龄孕产妇比较发现,出生缺陷发生率差异存在统计学意义(χ2=161.9,P<0.05)。结论蚌埠市的出生缺陷发生率为5.29%,与国内外的发生率相一致。提出母亲的文化程度,母亲孕早期用药、接触有害物质、接触宠物,母亲吸烟饮酒可能是出生缺陷的影响因素。Objective To learn about the spread of birth defects（BD） of 0 to 5 years old children in Bengbu City,and search for the possible factors. Methods Sampling the proportion group of different levels among all babies of 0 to 5 years old. All defects were diagnosed or confirmed by doctors. The relate factors of birth defects, such as the age of mother, disease, medicine, poison and smoking, etc. were investigated and analyzed statistically. And then put forward the possible dangers. Results Among 16 698 children of 0 to 5 ）,ears old, 833 of BD cases were testified and BD rate was 883/16 698 （5.29%）. Comparing pregnant women of different age ,the paper discovers that the differences in the birth defects rate had statistical meamng（Х^2 = 161.9 ,P 〈 0.05 ）. Conclusions The birth defect rate in Bengbu City is 5.29%, consistent with the rate of home and abroad. The dangerous factors leading to birth defects are history of deliver deformity, poisonous substance contacted, medicine consumed and pets contacted during the pregnancy.

关 键 词：出生缺陷 危险因素 母亲 

分 类 号：R722.1[医药卫生—儿科]