急性冠脉综合征患者血清C反应蛋白、血脂的变化及关系探讨  

The relation between CRP and lipid in patients with acute coronary syndrome and its clinic value

作　　者：陈以初[1] 王少波[1] 罗进才[1] 杨蕾[1] 周善存[1] 

机构地区：[1]东莞市厚街医院内一科,广东东莞523945

出　　处：《国际医药卫生导报》2008年第21期19-21,共3页International Medicine and Health Guidance News

摘　　要：目的探讨C反应蛋白（CRP）及血脂在急性冠脉综合征（ACS）患者中的临床意义。方法通过比较54例急性冠脉综合征，28例稳定型心绞痛（SAP）及25例健康正常人的CRP及血脂变化，以及分析其相关性，从而了解二者在急性冠脉综合征发病中的作用。结果ACS组的CRP（12．3±7．60）mg／L、TG（1．56±0．87）mmol／L、HDL-C（1．32±0．45）mmol／L、LDL-C（3．72±1．35）mmol／L；SAP组的CRP（8．01±5．46）mmol／L、TG（1．52±0．78）mm01／L，HDL-C（1．35±0．51）mmol／L、LDL—C（2．34±1．02）mmol／L；对照组的CRP（7．86土5．52）mmol／L、TG（1．54±0．81）mmol／L、HDL-C（1．34±0．48）mmol／L、LDL—C（2．47±1．08）mmol／L。ACS组的CRP及LDL-C水平较SAP组及对照组明显升高（P均〈0．05），而3组间的TG及HDL—C水平比较无明显差异（P〉0．05）。各组的CRP分别与TG、HDL-C、LDL-C进行相关分析，均无直线相关性。结论血清CRP及LDL-C水平与ACS发病有关，可能是ACS发病及预后判断的独立观察指标。Objective To investigate the clinic value of C-reactive protein（CRP）and lipid on patients wit acute coronary syndrome（ACS）.Methods The serum levels of CRP and lipid were measured in all patients and healthy control group. Comparing the two parameters in different group and analyzing the correlation between CRP and lipid in same group. Results In ACS group, the serum level of CRP was （12.3±7.60）mg/L, TG was （1.56±0.87）mmol/L, HDL-C was （1.32± 0. 45）mmol/L, LDL-C was （3. 72 ± 1.35）mmol/L . In SAP group, the serum level of CRP was （8. 01 ± 5.46）mmol/L, TG was （1.52 ± 0. 78）mmol/L, HDL-C was （1.35 ± 0. 51）mmol/L, LDL-C was （2.34± 1. 02） mmol/L. In control group, the serum level of CRP was （7.86±5.52）mmol/L, TG was （1.54 ±0. 81）mmol/L. HDL-C was （1.34 ± 0. 48）mmol/L, LDL-C was （2.47 ± 1.08）mmol/L The serum levels of CRP and LDL-C were higher in ACS group than that in SAP group and in control group. There was not significantly difference between TG and HDL-C in three groups. There were not positive linear correlations between CRP and TG, HDL-C, LDL-C in all groups, respectively. Conclusion The serum levels of CRP and LDL-C are associated with the genesis of ACS, and are the indicator of diagnosis and prognosis for patients with ACS.

关 键 词：急性冠脉综合征 C反应蛋白 血脂 

分 类 号：R541[医药卫生—心血管疾病]