辛伐他汀调脂治疗冠心病的疗效观察  

The efficacy and safety of simvastatin in treatment of patients with coronary heart disease

作　　者：李蓉[1] 邹立新 

机构地区：[1]长沙黄花国际机场医疗救护中心,湖南长沙410137 [2]长沙市第四人民医院,湖南长沙410006

出　　处：《国际医药卫生导报》2008年第22期59-61,共3页International Medicine and Health Guidance News

摘　　要：目的观察不同剂量辛伐他汀治疗冠心病伴高血脂症的疗效及不良反应。方法将100例冠心病伴高血脂症患者随机分为3组，A组给予辛伐他汀10mg／d口服，B组给予辛伐他汀20mg／d口服，C组给予辛伐他汀40mg／d口服。3组分别在治疗前及治疗过程中定期检测血清胆固醇（TC）、低密度脂蛋白（LDL—C）等及安全性指标（ALT、Cr、BUN及CK），比较不同剂量辛伐他汀的疗效及安全性。结果辛伐他汀常规剂量降低TC、LDL—C的作用显著，且不良反应较少。结论辛伐他汀常规剂量治疗冠心病伴高血脂症可取得较满意疗效。Objective To evaluate the efficacy and safety of different doses of simvastatin in treatment of patients with coronary heart disease （CHD）.Methods 100 patients with definite diagnosis of CHD were enrolled and divided into three groups treated with 10 mg （n=40）,20mg （n=40） and 40mg（n=20） simvastatin, once each night, respectively. The fasting serum levels of total cholesterol （TC）,low-density lipoprotein cholesterol （LDL-C）,as well as functions of liver and kidney were determined before medication, 12th and 24th week after initial medication ,respectively. Results The levels of TC and LDL-C levels in 20 mg group were continuously lower and the adverse effects including abnormal liver enzyme in 20mg group was fewer. Conclusion The simvastatin 20 mg in treatment of CHD is safe and more effective in lowering cholesterol ,causing more CHD cases to reach the target level of cholesterol.

关 键 词：辛伐他汀 冠心病 高血脂症 

分 类 号：R541[医药卫生—心血管疾病] R589[医药卫生—内科学]