甘草酸对哮喘小鼠肺组织Eotaxin表达的影响  

Effect of Glycyrrhizin on Eotaxin Expression in Lung Tissue in Asthmatic Model Mice

作　　者：吕小华[1] 吴铁[1] 覃冬云[1] 

机构地区：[1]广东医学院药理学教研室,湛江市524023

出　　处：《中国药房》2008年第31期2412-2414,共3页China Pharmacy

基　　金：广东省社会发展领域科技计划项目(No73044)

摘　　要：目的:观察甘草酸对哮喘小鼠肺组织嗜酸细胞活化趋化因子(Eotaxin)表达的影响,探讨甘草酸抗支气管哮喘的可能机制。方法:小鼠分为(哮喘)模型组、激素(强的松)组、甘草酸组和正常对照组,建立卵蛋白哮喘模型后给予相应药物,4周后处死小鼠,计数各组支气管肺泡灌洗液中嗜酸粒细胞及通过免疫组化检测各组肺组织中Eotaxin的表达,并与正常对照组比较。结果:与模型组比较,甘草酸能显著降低嗜酸粒细胞计数(P<0.01)及抑制肺组织Eotaxin的表达(P<0.05)。结论:甘草酸可能通过下调Eotaxin的表达而发挥抗嗜酸粒细胞性气道炎症的作用。OBJECTIVE： To explore the effect of glycyrrhizin on eotaxin expression in lung tissue from asthmatic model mice and the mechanism for glycyrrhizin to treat bronchial asthma. METHODS： The mice were randomized to asthma model group, prednisone- treated group and glycyrrhizin- treated group and normal control group. Egg protein asthma mouse model was established before being giving the corresponding drugs. Then the mice were sacrificed after 4 weeks for the counting of eosinophils in bronchoalveolar lavage fluid （BALF） and detection of Eotaxin expression in lung tissues by immunohistochemistry, with the results compared with normal control group. RESULTS： In glycyrrhizin- treated group compared with model group, the counting of eosinophils in BALF were decreased（P〈0.01） and the protein expression of Eotaxin were inhibited （P 〈 0.05）. CONCLUSIONS ： Glycyrrhizin demonstrated anti - inflammatory effects：by down - regulation of eotaxin.

关 键 词：甘草酸 支气管哮喘 小鼠 嗜酸细胞活化趋化因子 

分 类 号：R965[医药卫生—药理学] R975.5[医药卫生—药学]