骨组织工程支架材料及其相关的研究进展  

Research progress of scaffold materials and related problems for bone tissue engineering

作　　者：陈艳梅[1] 奚廷斐[2] 郑裕东[1] 

机构地区：[1]北京科技大学材料科学与工程学院,北京100083 [2]中国药品生物制品检定所,北京100050

出　　处：《北京生物医学工程》2008年第5期541-546,共6页Beijing Biomedical Engineering

基　　金：国家973计划(2007CB936101)资助

摘　　要：骨缺损的修复一直是长期以来不断深入研究的重点课题之一。随着组织工程学的兴起,组织工程的原理和技术逐步被应用于人工骨的构建。本文综述了骨组织工程支架材料的种类及复合支架材料的性能、生物学效应和生物安全性评价方法,同时简介了一种新型的具有三维空间网络结构的纳米支架材料——细菌纤维素,其与羟基磷灰石的复合材料作为骨修复和重建材料具有更好的应用前景。The research of bone defect restoration is one of the important research projects recently. With the development of tissue engineering, its principle and technology are used to prepare artificial bone with tissue engineering emerging. The type, performance, biological effect and bio-safely evaluation of scaffold materials for tissue engineering are all mentioned in this article. At the same time, bacterial cellulose （ BC ） , a kind of novel nano-grade scaffoht materials with 3D-network structure, is introduced. And more the composite of BC and hydroxyapatite （HA） possesses an excellent perspective in bone defect restoration and restitution.

关 键 词：支架材料 纳米 生物学效应 安全性评价 

分 类 号：R318.08[医药卫生—生物医学工程]