原位聚合法制备壳聚糖/聚丙烯酸水凝胶磁微球及其性能表征  

Chitosan-Poly (acrylic acid) Magnetic Microspheres Prepared by in situ Polymerization Method and their Characterization

作　　者：揭少卫[1] 杨黎明[1] 陈捷[1] 单廷[1] 钱锵[1] 

机构地区：[1]上海大学环境与化学工程学院,上海201800

出　　处：《高校化学工程学报》2008年第5期850-854,共5页Journal of Chemical Engineering of Chinese Universities

基　　金：上海市第二期重点学科(T0105)

摘　　要：为了避免制备过程中有机试剂对水凝胶磁微球生物安全性的影响,采用原位聚合法,在水溶液体系中制备了壳聚糖/聚丙烯酸(CS/PAAc)水凝胶磁微球。首先将壳聚糖(CS)包覆于纳米磁微球(Fe3O4)表面,随后加入丙烯酸单体,使其在壳聚糖磁微球上吸附并且原位聚合,然后经戊二醛交联得到了CS/PAAc水凝胶磁微球。用红外光谱、扫描电镜对合成的水凝胶磁微球进行了结构表征和形貌观察,并且进行了热重分析、元素分析、磁性能测试和粒度分析;研究了pH对水凝胶磁微球溶胀性能的影响。结果表明CS/PAAc水凝胶磁微球具有较好的球形结构,大小在500nm左右;Fe3O4含量约为73%,具有良好的顺磁性质,磁饱和强度为45emu·g-1;呈现出良好的pH敏感性,当pH=3时,CS/PAAc水凝胶磁微球的溶胀率达到最小。In order to enhance the bio-safety of the hydrogel magnetic microspheres and avoid staining it with the organic solvent used during its preparation, the chitosan-poly（acrylic acid） （CS-PAAc） magnetic microspheres were prepared by in situ polymerization method in an aqueous system. Chitosan （CS） was coated first on the surface of Fe3O4 nanoparticles, followed by acrylic acid attaching on the CS magnetic mierospheres and then polymerizing in situ. The CS-PAAc magnetic microspheres were obtained after crosslinking by glutaraldehyde. The physicochemical properties of prepared CS-PAAc magnetic microspheres were investigated by FT-IR, scanning electron microscope （SEM）, thermal gravimetric analysis （TGA）, element analysis, vibrating-sample magnetometer （VSM）, and laser particle analyzer （LSD）. The result shows that the prepared CS-PAAc magnetic microspheres possess a good sphericity with an average diameter of 500 nm and have a superparamagnetic property with the saturation magnetization of 45 emu.g^-1. The quantity of Fe304 in the prepared CS-PAAc magnetic microspheres is about 73 %（wt）. The effect ofpH on swelling ratio of the prepared CS-PAAc magnetic microspheres was studied. It was found that the prepared CS-PAAc magnetic microspheres show good pH-sensitivity; and its smallest swelling ratio is at pH=3.

关 键 词：壳聚糖 丙烯酸 水凝胶 磁微球 PH敏感性 

分 类 号：O648.17[理学—物理化学] TQ427.26[理学—化学]