钙通道阻滞剂和血管紧张素受体拮抗剂联合应用老年高血压患者的临床观察  

Combination of calcium channel-locking agents and angiotensin receptors antagonist for the prevention of cardio-cerebro-vascular events in elderly hypertensive patients

作　　者：林青[1] 吴霖[1] 金翠燕[1] 

机构地区：[1]上海市交通大学附属瑞金医院老年病科,200025

出　　处：《中国心血管杂志》2008年第5期334-336,共3页Chinese Journal of Cardiovascular Medicine

摘　　要：目的观察血管紧张素受体拮抗剂(ARB)和长效钙通道阻滞剂(CCB)联合应用,对减少合并危险因素老年高血压患者心脑血管事件是否优于单独使用。方法355例合并危险因素的老年高血压患者,分为ARB组(106例)、CCB组(115例)及联合治疗组(134例),随访5年,观察各组发生心脑血管事件的例数,并进行统计分析。结果联合治疗组心脑血管事件的发生率[3.7%(5/134)]明显低于ARB组[10.4%(11/106)]和CCB组[10.4%(12/115)],差异均有统计学意义(P<0.05);ARB组和CCB组的心脑血管事件发生差异无统计学意义(P>0.05)。结论联合应用ARB和CCB,较单独应用这两种药物,可进一步降低合并危险因素老年高血压患者的心脑血管事件,这种作用可能独立于降压作用之外。Objective To evaluate whether the combination therapy with angiotensin receptors antagonist （ARB） and calcium channel-blocking agents （CCB） has superiority in reducing cardio-cerebro-vascular events, compared to using each drug alone. Methods A total of 355 elderly hypertensive patients were enrolled in the study, all of them had other risk factors. They were divided into 3 groups for different therapies： ARB group ; CCB guoup and combination therapy group. We investigate the incidence of cariac-cerebullar vascular events in the following 5 years. Results The incidence of cariac-cerebuUar vascular events was significantly reduced in the combination therapy group compared with ARB group （P = 0. 036） and CCB group （ P = 0. 033 ）. And there was no significant difference between ARB group and CCB group （ P = 0.989）. Conclusion Combination therapy of ARB and CCB can further reduce the incident of cardio-eerebrovascularevents in elderly hypertensive patients with other risk factors.

关 键 词：钙通道阻滞药 受体 血管紧张素 危险因素 

分 类 号：R544.1[医药卫生—心血管疾病]