Asymmetric bioreduction of substituted acenaphthenequinones using plant enzymatic systems:A novel strategy for the preparation of(+)- and(-)-mono hydroxyacenaphthenones  

作　　者：Lian Peng Tong Jing Nan Cui Wei Min Ren Xing Yong Wang Xu Hong Qian 

机构地区：[1]State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, China [2]Shanghai Key Laboratory of Chemical Biology, East China University of Science and Technology, Shanghai 200237, China

出　　处：《Chinese Chemical Letters》2008年第10期1179-1182,共4页中国化学快报（英文版）

基　　金：the Program for Changjiang Scholars,the Innovative Research Team in University(No.IRT0711);the Technology Foundation of Shanghai(No.04DZ05605)for financial support of the research.

摘　　要：Regio- and enantioselective reduction of substituted acenaphthenequinones were conducted under mild reaction conditions using plant enzymatic systems. A screening of 15 plants allowed the selection of two suitable plants fulfilling enantiocomple- mentarity. The （＋）- and （-）-mono hydroxyacenaphthenones were achieved with high conversion and good enantiomeric purity using peach （Prunus persica （L.） Batsch., conversion 98%, 71% ee） and carrot （Daucus carota L., conversion 95%, 81% ee）, respectively.Regio- and enantioselective reduction of substituted acenaphthenequinones were conducted under mild reaction conditions using plant enzymatic systems. A screening of 15 plants allowed the selection of two suitable plants fulfilling enantiocomple- mentarity. The （＋）- and （-）-mono hydroxyacenaphthenones were achieved with high conversion and good enantiomeric purity using peach （Prunus persica （L.） Batsch., conversion 98%, 71% ee） and carrot （Daucus carota L., conversion 95%, 81% ee）, respectively.

关 键 词：BIOREDUCTION Plant enzymes ACENAPHTHENEQUINONE Chiral hydroxyacenaphthenone 

分 类 号：O64[理学—物理化学]