深加工对补骨脂浸出物及其补骨脂素、异补骨脂素含量的影响  

The Influence of Further Processing on Psoralea corylifolia Alcohol Extracts and the Content of Psoralen and Isopsoralen

作　　者：朱广平[1] 邵家德[1] 吴旭彤[1] 邹小娟[2] 邵乾[1] 

机构地区：[1]江苏省中医院,江苏南京210029 [2]南京中医药大学,江苏南京210029

出　　处：《中药材》2008年第10期1479-1481,共3页Journal of Chinese Medicinal Materials

摘　　要：目的:改进补骨脂加工炮制方法。方法:将补骨脂用自制轧药机轧扁至裂开,与未轧的药材分别加水或乙醇提取,以水或醇溶性浸出物量及其补骨脂素、异补骨脂素含量为考察指标,用高效液相色谱法测定,条件为:Supelco ODS C18柱,柱温30℃,流动相为甲醇-水(43∶57),检测波长为246 nm。结果:在相同条件下,补骨脂轧扁样品的水或醇溶性浸出物量及其补骨脂素、异补骨脂素含量均比未轧的整粒高,其中,水溶性浸出物增加了0.61倍,醇溶性浸出物增加了1.53倍,水溶性及醇溶性浸出物中补骨脂素、异补骨脂素含量均增加了1.22倍,两者得率悬殊,差异显著。结论:补骨脂经轧扁法加工后能显著提高浸出物量及其有效成分的提取率,增进临床疗效,方法合理,值得推广。Objective ： To improve the processing method of Psoralea corylifolia. Methods ： The self-made processing machine was used to flatten Psoralea corylifolia. Then it was extracted with water soluble and alcohol soluble with Psoralea corylifolia unflatten as the amount of Psoralea corylifolia and the content of psoralen and isopsoralen were factors. HPLC was used. The analytical column was a Supelco ODS-CI8. The mobile phase consisted of methanol-water（43： 57）. The detector wavelength was 246 nm. The column tempera- ture was 30℃. Results ： Under the same condition, the conditioning treatment increased the water or ethanol extracting amount of Psoralea corylifolia and the content of psoralen and isopsoralen of the processing samples compared with the unconditioning treatment. The amount of water soluble extracts and erhanol soluble extracts increased 0. 61 times and 1.53 times, respectively. And the content of psoralen and isopsoralen in water soluble and ethanol soluble extracts increased 1.22 times. Conclusion： The method to flatten Psoralea corylifolia can significantly improve the content of extraction and extraction rate of active components. It can also enhance the clinical effectiveness. The method is reasonable and deserves to be popularized.

关 键 词：补骨脂 轧扁 浸出物 补骨脂素 异补骨脂素 

分 类 号：R283[医药卫生—中药学]